Insulin Lispro-aabc (By injection)
Insulin Lispro-aabc, Recombinant (IN-su-lin LIS-pro - aabc, ree-KOM-bi-nant)
Lyumjev KwikPen U-100, Lyumjev Kwikpen U-200, Lyumjev U-100There may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. Do not use it if you had an allergic reaction to insulin lispro-aabc or during an episode of low blood sugar.
How to Use This Medicine:
- IV: A nurse or other health professional may give you this medicine into a vein if you are in the hospital.
- Your healthcare provider will work with you to personalize your dose and treatment based on your insulin needs and lifestyle. You will be taught how to give yourself the injections. Make sure you understand all instructions. Ask the doctor, nurse, or pharmacist if you have questions.
- SC: This medicine is also given as a shot under the skin of your stomach, thigh, buttocks, or upper arm.
- Always double-check both the concentration (strength) of your insulin and your dose. Concentration and dose are not the same. The dose is how many units of insulin you will use. The concentration tells how many units of insulin are in each milliliter (mL), such as 100 units/mL (U-100), but this does not mean you will use 100 units at a time.
- When used as a mealtime insulin, it should be taken at the start of a meal or within 20 minutes after you start a meal.
- You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not use the exact same spot for each injection.
- Do not inject into skin areas that are tender, bruised, scaly, hard, damaged, thick, or has pits, lumps, or scars.
- The insulin solution should look clear and colorless. Do not use it if it is thick, cloudy, discolored, or if there are lumps or particles in it.
- KwikPen®, Tempo Pen, or Junior KwikPen®:
- Wash your hands with soap and water.
- Prime the pen by removing the air from the needle and cartridge. Select 2 units when turning the dose knob.
- Hold the pen with the needle pointing up, then gently tap the cartridge holder to collect the air bubbles at the top.
- Push the dose knob until it stops. You should see a "0" in the dose window. Hold the dose knob in and slowly count to 5.
- You should see insulin at the needle tip. If you do not see insulin, repeat the priming steps but not more than 4 times. If there is still no insulin, change the needle then repeat the priming steps.
- If your dose is more than 60 units (30 units for Junior KwikPen®), you will need to give more than 1 injection. Use a new needle for each injection and repeat the priming steps.
- When taking your dose, turn the dose knob to select the number of units you need to inject. The pen dials 1 unit (0.5 unit for Junior KwikPen®) at a time and the dose knob clicks as you turn it. Do not dial your dose by counting the clicks as this can lead to you getting too much or too little insulin.
- Insert the needle into your skin and push the knob all the way in. Continue to hold it, then slowly count to 5 before removing it.
- If you see "0" in the dose window, you have received the full dose. Do not redial if you do not see a "0". Reinsert the needle into your skin and finish the injection.
- If you need 2 injections for a full dose, be sure to take the second injection.
- Use a new needle each time you give yourself an injection. Always remove and throw the needle after each injection. Store the pen without a needle attached. Do not use the pen if it is broken or damaged.
- Wash your hands with soap and water.
- Use only syringes that are made for insulin injections. Use a new syringe and needle each time you give yourself an injection.
- Do not mix this medicine with any other insulin.
- Do not transfer Lyumjev U-200 from the prefilled pen to a syringe for use.
- Always check the label before use to make sure you have the correct type of insulin. Do not change the brand, type, or concentration unless your doctor tells you to. Do not use an infusion pump or other device to use this medicine.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Missed dose: Call your doctor or pharmacist for instructions.
- Unopened medicine: Store unused vials, pens, or cartridges in the refrigerator. Do not freeze. Do not use the insulin if it has been frozen. You may also keep them at room temperature for up to 28 days. Throw away any unused medicine after 28 days.
- Opened medicine: Store the opened pens and cartridges at room temperature for up to 28 days. Do not refrigerate. You may keep the opened vials in the refrigerator or at room temperature for up to 28 days. Do not freeze. Throw away any unused medicine after 28 days.
- Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines can change the amount of insulin you need to use and make it harder for you to control your diabetes. Make sure your doctor knows about all other medicines that you are using.
- Do not drink alcohol while you are using this medicine.
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, or heart failure.
- This medicine may cause the following problems:
- Low blood sugar or low potassium levels in the blood
- Fluid retention or heart failure (when used together with a thiazolidinedione [TZD] medicine)
- This medicine may make you less alert than you are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Never share insulin pens, cartridges, or needles with anyone. Sharing these can pass hepatitis viruses, HIV, and other illnesses from one person to another.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dry mouth, increased thirst, muscle cramps, nausea or vomiting, uneven heartbeat
- Fever, stuffy or runny nose, muscle aches, sore throat, headache
- Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness
- Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
If you notice these less serious side effects, talk with your doctor:
- Redness, itching, swelling, or any skin changes where the shot is given
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 6/10/2021