Fragment D-dimer; Fibrin degradation fragment; DVT - D-dimer; PE - D-dimer; Deep vein thrombosis - D-dimer; Pulmonary embolism - D-dimer; Blood clot to the lungs - D-dimer
D-dimer tests are used to check for blood clotting problems. Blood clots can cause health problems, such as:
The D-dimer test is a blood test. You will need to get a blood sample drawn.
No special preparation is necessary.
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging sensation. Afterward, there may be some throbbing or a slight bruise.
Your health care provider may order a D-dimer test if you are showing symptoms of blood clots, such as:
Your provider may also use the D-dimer test to see if treatment for DIC is working.
A normal test is negative. This means that you probably do not have problems with blood clotting.
If you are getting the D-dimer test to see if treatment is working for DIC, a normal or decreasing level of D-dimer means the treatment is working.
A positive test means that you may be making blood clots. The test does not tell where the clots are or why you are making clots. Your provider may order other tests to see where clots are located.
A positive test may be caused by other factors, and you may not have any clots. D-dimer levels can be positive due to:
This makes the test mostly useful when it is negative or when many of the above causes can be ruled out.
Veins vary in size from one person to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Risks of having blood drawn are slight, but may include:
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Kabrhel C. Pulmonary embolism and deep vein thrombosis. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 74.
Lim W, Le Gal G, Bates SM, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism. Blood Adv. 2018;2(22):3226-3256. PMID: 30482764 pubmed.ncbi.nlm.nih.gov/30482764/.
Siegal D, Lim W. Venous thromboembolism. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 142.BACK TO TOP
Review Date: 1/9/2022
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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