Sestamibi stress test; MIBI stress test; Myocardial perfusion scintigraphy; Dobutamine stress test; Persantine stress test; Thallium stress test; Stress test - nuclear; Adenosine stress test; Regadenoson stress test; CAD - nuclear stress; Coronary artery disease - nuclear stress; Angina - nuclear stress; Chest pain - nuclear stress
Nuclear stress test is an imaging method that uses radioactive material to show how well blood flows into the heart muscle, both at rest and during activity.
This test is done at a medical center or health care provider's office. It is done in stages:
You will have an intravenous (IV) line started.
Most people will then walk on a treadmill (or pedal on an exercise machine).
Your blood pressure and heart rhythm (ECG) will be monitored throughout the test.
When your heart is working as hard as it can, a radioactive substance is again injected into one of your veins.
Your provider will compare the first and second set of pictures using a computer. This can help detect if you have heart disease or if your heart disease is becoming worse.
You should wear comfortable clothes and shoes with non-skid soles. You may be asked not to eat or drink after midnight. You will be allowed to have a few sips of water if you need to take medicines.
You will need to avoid caffeine for 24 hours before the test. This includes:
Many medicines can interfere with blood test results.
During the test, some people feel:
If you are given the vasodilator drug, you may feel a sting as the medicine is injected. This is followed by a feeling of warmth. Some people also have a headache, nausea, and a feeling that their heart is racing.
If you are given medicine to make your heart beat stronger and faster (dobutamine), you may have a headache, nausea, or your heart may pound faster and more strongly.
Rarely, during the test people experience:
If any of these symptoms occur during your test, tell the person performing the test right away.
The test is done to see if your heart muscle is getting enough blood flow and oxygen when it is working hard (under stress).
Your provider may order this test to find out:
The results of a nuclear stress test can help:
A normal test most often means that you were able to exercise as long as or longer than most people of your age and sex. You also did not have symptoms or changes in blood pressure, your ECG or the images of your heart that caused concern.
A normal result means blood flow through the coronary arteries is probably normal.
The meaning of your test results depends on the reason for the test, your age, and your history of heart and other medical problems.
Abnormal results may be due to:
After the test you may need:
Complications are rare, but may include:
Your provider will explain the risks before the test.
In some cases, other organs and structures can cause false-positive results. However, special steps can be taken to avoid this problem.
You may need additional tests, such as cardiac catheterization, depending on your test results.
Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;64(24):e139-e228. PMID: 25260718 pubmed.ncbi.nlm.nih.gov/25260718/.
Dorbala S, DiCarli MF. Nuclear cardiology. In: Libby P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Philadelphia, PA: Elsevier; 2022:chap 18.
Fihn SD, Blankenship JC, Alexander KP, et al. 2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2014;64(18):1929-1949. PMID: 25077860 pubmed.ncbi.nlm.nih.gov/25077860/.
Flink L, Phillips L. Nuclear cardiology. In: Levine GN, ed. Cardiology Secrets. 6th ed. Philadelphia, PA: Elsevier; 2023:chap 8.BACK TO TOP
Review Date: 10/5/2022
Reviewed By: Thomas S. Metkus, MD, Assistant Professor of Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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