A vesicle is a small fluid-filled blister on the skin.
A vesicle is small. It may be as tiny as the top of a pin or up to 5 millimeters wide. A larger blister is called a bulla.
In many cases, vesicles break easily and release their fluid onto the skin. When this fluid dries, yellow crusts may remain on the skin surface.
Many diseases and conditions can cause vesicles. Common examples include:
It is best to have your health care provider examine any skin rashes, including vesicles.
Over-the-counter treatments are available for certain conditions that cause vesicles, including poison ivy and cold sores.
Call your provider if you have any unexplained blisters on your skin.
Your provider will look at your skin. Some vesicles can be diagnosed simply by how they look.
In many cases, additional tests are needed. The fluid inside a blister may be sent to a lab for closer examination. In particularly difficult cases, a skin biopsy may be needed to make or confirm a diagnosis.
Treatment will depend on the cause of the vesicles.
Dinulos JGH. Vesicular and bullous diseases. In: Dinulos JGH, ed. Habif's Clinical Dermatology. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 16.
Marks JG, Miller JJ. Vesicles and bullae. In: Marks JG, Miller JJ, eds. Lookingbill and Marks' Principles of Dermatology. 6th ed. Philadelphia, PA: Elsevier; 2019:chap 10.BACK TO TOP
Review Date: 6/19/2021
Reviewed By: Ramin Fathi, MD, FAAD, Director, Phoenix Surgical Dermatology Group, Phoenix, AZ. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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