Biopsy - synovial membrane; Rheumatoid arthritis - synovial biopsy; Gout - synovial biopsy; Joint infection - synovial biopsy; Synovitis - synovial biopsy
A synovial biopsy is the removal of a piece of tissue lining a joint for examination. The tissue is called the synovial membrane.
The test can be done in the operating room or in the physician's office. There are multiple techniques used for synovial biopsy including surgery, arthroscopy or ultrasound guided needle biopsy.
During this procedure:
If you are having an arthroscopic procedure:
If you are having a needle biopsy:
Follow your health care provider's instructions on how to prepare. This may include not eating and drinking anything for several hours before the procedure.
With the local anesthetic, you will feel a prick and a burning sensation. As the trocar is inserted, there will be some discomfort. If the surgery is performed under regional or general anesthesia, you will not feel the procedure.
Synovial biopsy helps diagnose gout and bacterial infections, or rule out other infections. It can be used to diagnose autoimmune disorders such as rheumatoid arthritis, or uncommon infections like tuberculosis or fungal infections.
The synovial membrane structure is normal.
Synovial biopsy may identify the following conditions:
There is a very slight chance of infection and bleeding.
Follow instructions for keeping the wound clean and dry until your provider says it is OK to get it wet.
El-Gabalawy HS, Tanner S. Synovial fluid analyses, synovial biopsy, and synovial pathology. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein and Kelley's Textbook of Rheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 56.
Johnsson H, Najm A. Synovial biopsies in clinical practice and research: current developments and perspectives. Clinical Rheumatology. 2021;40(7):2593-2600. PMID: 33274415 pubmed.ncbi.nlm.nih.gov/33274415/.
West SG. Synovial biopsies. In: West SG, Kolfenbach J, eds. Rheumatology Secrets. 4th ed. Philadelphia, PA: Elsevier; 2020:chap 9.BACK TO TOP
Review Date: 7/21/2022
Reviewed By: Diane M. Horowitz, MD, Rheumatology and Internal Medicine, Northwell Health, Great Neck, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Health Content Provider
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2023 A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.