Biopsy - liver; Percutaneous liver biopsy; Needle biopsy of liver
A liver biopsy is a test that takes a sample of tissue from the liver for examination.
Most of the time, the test is done in the hospital. Before the test is done, you may be given a medicine to prevent pain or to calm you (sedative).
The biopsy may be done through the abdominal wall:
The procedure can also be done by inserting a needle into the jugular vein.
If you receive sedation for this test, you will need someone to drive you home.
Tell your provider about:
You must sign a consent form. Blood tests are sometimes done to test your blood's ability to clot. You will be told not to eat or drink anything for the 8 hours before the test.
For infants and children:
The preparation needed for a child depends on the child's age and maturity. Your child's provider will tell you what you can do to prepare your child for this test.
You will feel a stinging pain when the anesthetic is injected. The biopsy needle may feel like deep pressure and dull pain. Some people feel this pain in the shoulder.
The biopsy helps diagnose many liver diseases. The procedure also helps assess the stage (early, advanced) of liver disease. This is especially important in hepatitis B and C infection.
The biopsy also helps detect:
The liver tissue is normal.
This test also may be performed for:
Risks may include:
Bedossa P, Paradis V, Zucman-Rossi J. Cellular and molecular techniques. In: Burt AD, Ferrell LD, Hubscher SG, eds. MacSween's Pathology of the Liver. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 2.
Chernecky CC, Berger BJ. Liver biopsy (percutaneous liver biopsy) - diagnostic. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:727-729.
Holmes JA, Chung RT. Hepatitis C. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 80.
Martin P. Approach to the patient with liver disease. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 137.BACK TO TOP
Review Date: 1/14/2021
Reviewed By: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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