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Myocardial biopsy

Heart biopsy; Biopsy - heart

Myocardial biopsy is the removal of a small piece of heart muscle for examination.

Images

Heart - section through the middle
Heart - front view
Biopsy catheter

How the Test is Performed

Myocardial biopsy is done through a catheter that is threaded into your heart (cardiac catheterization). The procedure will take place in a hospital radiology department, special procedures room, or cardiac diagnostics laboratory.

To have the procedure:

How to Prepare for the Test

You will be told not to eat or drink anything for 6 to 8 hours before the test. The procedure takes place in the hospital. Most often, you will be admitted the morning of the procedure, but in some cases, you may need to be admitted the night before.

A health care provider will explain the procedure and its risks. You must sign a consent form.

How the Test will Feel

You may feel some pressure at the biopsy site. You may have some discomfort due to lying still for a long period of time.

Why the Test is Performed

This procedure is routinely done after heart transplantation to watch for signs of rejection.

Your provider may also order this procedure if you have signs of:

Normal Results

A normal result means no abnormal heart muscle tissue was discovered. However, it does not necessarily mean your heart is normal because sometimes the biopsy can miss abnormal tissue.

What Abnormal Results Mean

An abnormal result means abnormal tissue was found. This test may reveal the cause of cardiomyopathy. Abnormal tissue may be due to:

Risks

Risks are moderate and include:

Related Information

Cardiomyopathy
Myocarditis
Cardiac amyloidosis
Transplant rejection
Hypertrophic cardiomyopathy
Peripartum cardiomyopathy
Restrictive cardiomyopathy

References

Kliger CA, Sorajja P. Special techniques. In: Sorajja P, Lim MJ, Kern MJ, eds. Kern's Cardiac Catheterization Handbook. 7th ed. Philadelphia, PA: Elsevier; 2020:chap 9.

Miller DV. Cardiovascular system. In: Goldblum JR, Lamps LW, McKenney JK, Myers JL, eds. Rosai and Ackerman's Surgical Pathology. 11th ed. Philadelphia, PA: Elsevier; 2018:chap 42.

Rogers JG, O'Connor CM. Heart failure: epidemiology, pathobiology, and diagnosis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 45.

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Review Date: 5/8/2024  

Reviewed By: Thomas S. Metkus, MD, Assistant Professor of Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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