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Myoglobin urine test

Urine myoglobin; Heart attack - myoglobin urine test; Myositis - myoglobin urine test; Rhabdomyolysis - myoglobin urine test

The myoglobin urine test is done to detect the presence of myoglobin in urine.

Myoglobin can also be measured with a blood test.

Images

Urine sample
Female urinary tract
Male urinary tract

How the Test is Performed

A clean-catch urine sample is needed. The clean-catch method is used to prevent germs from the penis or vagina from getting into a urine sample. To collect your urine, the health care provider may give you a special clean-catch kit that contains a cleansing solution and sterile wipes. Follow instructions exactly so that the results are accurate.

How the Test will Feel

The test involves only normal urination, which should cause no discomfort.

Why the Test is Performed

Myoglobin is a protein in heart and skeletal muscles. When you exercise, your muscles use up available oxygen. Myoglobin has oxygen attached to it, which provides extra oxygen for the muscles to keep up a high level of activity for a longer period.

When muscle is damaged, myoglobin in muscle cells is released into the bloodstream. The kidneys help remove myoglobin from the blood into the urine. When the level of myoglobin is too high, it can damage the kidneys.

This test is ordered when your provider suspects you have muscle damage, such as damage to the heart or skeletal muscle. It may also be ordered if you have acute kidney failure without any clear cause.

Normal Results

A normal urine sample does not have myoglobin. A normal result is sometimes reported as negative.

Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test results.

What Abnormal Results Mean

Abnormal results may be due to:

Risks

There are no risks with this test.

Related Information

Acute kidney failure
Myositis
Heart attack
Muscular dystrophy
Rhabdomyolysis
Malignant hyperthermia

References

Chernecky CC, Berger BJ. Myoglobin, qualitative - urine. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:808.

Nagaraju K, Aggarwal R, Lundberg IE. Inflammatory diseases of muscle and other myopathies. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelly's Textbook of Rheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 90.

Selcen D. Muscle diseases. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 393.

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Review Date: 1/24/2021  

Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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