Urine protein - 24 hour; Chronic kidney disease - urine protein; Kidney failure - urine protein
A 24-hour urine protein measures the amount of protein released in urine over a 24-hour period.
A 24-hour urine sample is needed:
For an infant, thoroughly wash the area around the urethra. Open a urine collection bag (a plastic bag with an adhesive paper on one end), and place it on the infant. For males, place the entire penis in the bag and attach the adhesive to the skin. For females, place the bag over the labia. Diaper as usual over the secured bag.
This procedure may take a couple of attempts. Active infants can move the bag, causing the urine to be absorbed by the diaper. The infant should be checked frequently and the bag changed after the infant has urinated into the bag. Drain the urine from the bag into the container provided by your health care provider.
Deliver it to the lab or your provider as soon as possible upon completion.
Your provider will tell you, if needed, to stop taking any medicines that may interfere with the test results.
A number of medicines can change the test results. Make sure your provider knows about all medicines, herbs, vitamins, and supplements you are taking.
The following may also affect test results:
The test involves only normal urination, and there is no discomfort.
Your provider may order this test if blood, urine, or imaging tests find signs of reduced kidney function.
To avoid a 24-hour urine collection, your provider may be able to order a test that is done on just one urine sample (protein-to-creatinine ratio).
The normal value is less than 100 milligrams per day or less than 10 milligrams per deciliter of urine.
The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.
Abnormal results may be due to:
Healthy people may have higher than normal urine protein level after strenuous exercise or when they are dehydrated. Some foods may affect urine protein levels.
The test involves normal urination. There are no risks.
Castle EP, Wolter CE, Woods ME. Evaluation of the urologic patient: testing and imaging. In: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, eds. Campbell-Walsh-Wein Urology. 12th ed. Philadelphia, PA: Elsevier; 2021:chap 2.
Hiremath S, Buchkremer F, Lerma EV. Urinalysis. In: Lerma EV, Sparks MA, Topf JM, eds. Nephrology Secrets. 4th ed. Philadelphia, PA: Elsevier; 2019:chap 2.
Krishnan A. Levin A. Laboratory assessment of kidney disease: glomerular filtration rate, urinalysis, and proteinuria. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 23.BACK TO TOP
Review Date: 10/19/2022
Reviewed By: Walead Latif, MD, Nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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