Fetal alpha globulin; AFP
Alpha fetoprotein (AFP) is a protein produced by the liver and yolk sac of a developing baby during pregnancy. AFP levels go down soon after birth. It is likely that AFP has no normal function in adults.
A test can be done to measure the amount of AFP in your blood.
A blood sample is needed. Most of the time, blood is typically drawn from a vein located on the inside of the elbow or the back of the hand.
You do not need to take any special steps to prepare.
You may feel slight pain or a sting when the needle is inserted. You may also feel some throbbing at the site after the blood is drawn.
Your health care provider may order this test to:
The normal values in males or nonpregnant females is generally less than 40 micrograms/liter.
The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.
Greater than normal levels of AFP may be due to:
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Carter N, Sharpless Chalk B. Neonatology. In: Kleinman K, Mcdaniel L, Molloy M, eds. The Harriet Lane Handbook. 22nd ed. Philadelphia, PA: Elsevier; 2021:chap 18.
Lee P, Jain S, Pincus MR, et al. Diagnosis and management of cancer using serologic and other body fluid markers. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 76.
Wapner RJ, Dugoff L. Prenatal diagnosis of congenital disorders. In: Resnik R, Lockwood CJ, Moore TR, Greene MF, Copel JA, Silver RM, eds. Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2019:chap 32.BACK TO TOP
Review Date: 7/13/2021
Reviewed By: John D. Jacobson, MD, Department of Obstetrics and Gynecology, Loma Linda University School of Medicine, Loma Linda, CA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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