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Progeria

Hutchinson-Gilford progeria syndrome; HGPS

Progeria is a rare genetic condition that produces rapid aging in children.

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Coronary artery blockage

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Causes

Progeria is a rare condition. It is remarkable because its symptoms strongly resemble normal human aging, but it occurs in young children. In most cases, it is not passed down through families. It is rarely seen in more than one child in a family.

Symptoms

Symptoms include:

Exams and Tests

The health care provider will perform a physical exam and order laboratory tests. This may show:

Cardiac stress testing may reveal signs of early atherosclerosis of blood vessels.

Genetic testing can detect changes in the gene (LMNA) that causes progeria.

Treatment

There is no specific treatment for progeria. Aspirin and statin medicines may be used to protect against a heart attack or stroke.

Support Groups

Progeria Research Foundation, Inc. -- www.progeriaresearch.org

Outlook (Prognosis)

Progeria causes early death. People with the condition most often only live to their teenage years (average lifespan of 14 years). However, some can live into their early 20s. The cause of death is very often related to the heart or a stroke.

Possible Complications

Complications may include:

When to Contact a Medical Professional

Contact your provider if your child does not appear to be growing or developing normally.

Related Information

Failure to thrive
Stroke
Heart attack

References

Gordon LB. Hutchinson-Gilford progeria syndrome (progeria). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 109.

Gordon LB, Brown WT, Collins FS, et al. Hutchinson-Gilford progeria syndrome. GeneReviews. 2015:1. PMID: 20301300 pubmed.ncbi.nlm.nih.gov/20301300/. Updated January 17, 2019. November 1, 2021.

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Review Date: 7/30/2021  

Reviewed By: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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