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Cleidocranial dysostosis

Cleidocranial dysplasia; Dento-osseous dysplasia; Marie-Sainton syndrome; CLCD; Dysplasia cleidocranial; Osteodental dysplasia

Cleidocranial dysostosis is a disorder involving the abnormal development of bones in the skull and collar (clavicle) area.


Cleidocranial dysostosis is caused by an abnormal gene. It is passed down through families as an autosomal dominant trait. That means you only need to get the abnormal gene from one parent in order for you to inherit the disease.

Cleidocranial dysostosis is a congenital condition, which means it is present from before birth. The condition affects girls and boys equally.


People with cleidocranial dysostosis have a jaw and brow area that sticks out. The middle of their nose (nasal bridge) is wide.

The collar bones may be missing or abnormally developed. This pushes the shoulders together in front of the body.

Primary teeth do not fall out at the expected time. Adult teeth may develop later than normal and an extra set of adult teeth grow in. This causes the teeth to become crooked.

Intelligence level is most often normal.

Other symptoms include:

Exams and Tests

The health care provider will take your family history. The provider will do a physical examination and may do series of x-rays to check for:


There is no specific treatment for it and management depends on each person's symptoms. Most people with the disease need:

Support Groups

More information and support for people with cleidocranial dysostosis and their families can be found at:

Outlook (Prognosis)

In most cases, the bone symptoms cause few problems. Appropriate dental care is important.

Possible Complications

Complications include dental problems and shoulder dislocations.

When to Contact a Medical Professional

Contact your provider if you have a:


Genetic counseling is appropriate if a person with a family or personal history of cleidocranial dysostosis is planning to have children. The disease may be diagnosed during pregnancy.


Hecht JT, Horton WA, Rodriguez-Buritica D. Disorders involving transcription factors. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 718.

Jones KL, Jones MC, del Campo M. Osteochondrodysplasia with osteopetrosis. In: Jones KL, Jones MC, del Campo M, eds. Smith's Recognizable Patterns of Human Malformation. 8th ed. Philadelphia, PA: Elsevier; 2022: 558-569.

Lissauer T, Carroll W. Musculoskeletal disorders. In: Lissauer T, Carroll W, eds. Illustrated Textbook of Paediatrics. 6th ed. Philadelphia, PA: Elsevier; 2022:chap 28.

National Center for Advancing Translational Sciences website. Genetic and Rare Diseases Information Center. Cleidocranial dysplasia. Updated January 2024. Accessed February 22, 2024.

National Institute of Health website. Genetics Home Reference. Cleidocranial dysplasia. Updated August 1, 2017. Accessed March 8, 2024.


Review Date: 2/17/2024  

Reviewed By: Charles I. Schwartz, MD, FAAP, Clinical Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, General Pediatrician at PennCare for Kids, Phoenixville, PA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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