Duodenal atresia is a condition in which the first part of the small bowel (the duodenum) has not developed properly. It is not open and cannot allow the passage of stomach contents.
The cause of duodenal atresia is not known. It is thought to result from problems during an embryo's development. The duodenum does not change from a solid to a tube-like structure, as it normally would.
Many infants with duodenal atresia also have Down syndrome. Duodenal atresia is often associated with other birth defects.
Symptoms of duodenal atresia include:
A fetal ultrasound may show high amounts of amniotic fluid in the womb (polyhydramnios). It may also show swelling of the baby's stomach and part of the duodenum.
An abdominal x-ray may show air in the stomach and first part of duodenum, with no air beyond that. This is known as the double-bubble sign.
A tube is placed to decompress the stomach. Dehydration and electrolyte imbalances are corrected by providing fluids through an intravenous tube (IV, into a vein). Checking for other congenital anomalies should be done.
Surgery to correct the duodenal blockage is necessary, but not an emergency. The exact surgery will depend on the nature of the abnormality. Other problems (such as those related to Down syndrome) must be treated as appropriate.
Recovery from the duodenal atresia is expected after treatment. If not treated, the condition is deadly.
These complications may occur:
After surgery, there may be complications such as:
Call your health care provider if your newborn is:
There is no known prevention.
Dingeldein M. Selected gastrointestinal anomalies in the neonate. In: Martin RJ, Fanaroff AA, Walsh MC, eds. Fanaroff and Martin's Neonatal-Perinatal Medicine. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 84.
Maqbool A, Bales C, Liacouras CA. Intestinal atresia, stenosis, and malrotation. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 356.
Semrin MG. Anatomy, histology, and developmental anomalies of the stomach and duodenum. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 49.BACK TO TOP
Review Date: 4/14/2021
Reviewed By: Charles I. Schwartz, MD, FAAP, Clinical Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, General Pediatrician at PennCare for Kids, Phoenixville, PA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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