Paralysis agitans; Shaking palsy; Parkinson's disease
Parkinson disease results from certain brain cells dying. These cells help control movement and coordination. The disease leads to shaking (tremors) and trouble walking and moving.
Nerve cells use a brain chemical called dopamine to help control muscle movement. With Parkinson disease, the brain cells that make dopamine slowly die. Without enough dopamine, the cells that control movement can't send proper messages to the muscles. This makes it hard to control the muscles. Slowly, over time, this damage gets worse. No one knows exactly why these brain cells waste away.
Parkinson disease most often develops after age 60. It is one of the most common nervous system problems in older adults.
Symptoms may be mild at first. For instance, you may have a mild tremor or a slight feeling that one leg is stiff and dragging. Jaw tremor has also been an early sign of Parkinson disease. Symptoms may affect one or both sides of the body.
General symptoms may include:
Movement problems may include:
Symptoms of shaking (tremors):
Other symptoms may include:
Your health care provider may be able to diagnose Parkinson disease based on your symptoms and a physical exam. But the symptoms may be hard to pin down, particularly in older adults. Symptoms are easier to recognize as the illness gets worse.
The examination may show:
Your provider may do some tests to check for other conditions that can cause similar symptoms. A DaTscan can show abnormalities suggesting Parkinson, but is only necessary in some situations.
There is no cure for Parkinson disease, but treatment can help control your symptoms.
MEDICINE
Your provider may prescribe medicines to help control your shaking and movement symptoms.
At certain times during the day, the medicine may wear off and symptoms can return. If this happens, your provider may need to change any of the following:
You may also need to take medicines to help with:
Parkinson medicines can cause side effects that may be severe, including:
Tell your provider right away if you have these side effects. Never change or stop taking any medicines without talking with your provider. Stopping some medicines for Parkinson disease may lead to a severe reaction. Work with your provider to find a treatment plan that works for you.
As the disease gets worse, symptoms such as stooped posture, frozen movements, and speech problems may not respond to the medicines.
SURGERY
Surgery may be an option for some people. Surgery does not cure Parkinson disease, but it may help ease symptoms. Types of surgery include:
LIFESTYLE
Certain lifestyle changes may help you cope with Parkinson disease:
Parkinson disease support groups can help you cope with the changes caused by the disease. Sharing with others who have common experiences can help you feel less alone.
Medicines can help most people with Parkinson disease. How well medicines relieve symptoms and for how long they relieve symptoms can be different in each person.
The disorder may get worse until a person is totally disabled, although in some people, this can take decades. Parkinson disease may lead to a decline in brain function and early death. Medicines may prolong function and independence.
Parkinson disease may cause problems such as:
Effects from loss of strength and mobility (debilitation):
Contact your provider if:
If you take medicines for Parkinson disease, tell your provider about any side effects, which may include:
Also contact your provider if the condition gets worse and home care is no longer possible.
Fox SH, Katzenschlager R, Lim SY, et al; Movement Disorder Society Evidence-Based Medicine Committee. International Parkinson and Movement Disorder Society evidence-based medicine review: update on treatments for the motor symptoms of Parkinson's disease. Mov Disord. 2018;33(8):1248-1266. PMID: 29570866 pubmed.ncbi.nlm.nih.gov/29570866/.
Goldman JG, Volpe D, Ellis TD, et al. Delivering Multidisciplinary Rehabilitation Care in Parkinson's Disease: An International Consensus Statement. J Parkinsons Dis. 2024;14(1):135-166. PMID: 38277303 pubmed.ncbi.nlm.nih.gov/38277303/.
Jankovic J. Parkinson disease and other movement disorders. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 96.
Ostrem JL, Okun MS. Parkinsonism. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 378.
Pringsheim T, Day GS, Smith DB, et al. Guideline Subcommittee of the AAN. Dopaminergic therapy for motor symptoms in early Parkinson disease practice guideline summary: a report of the AAN Guideline Subcommittee. Neurology. 2021;97(20):942-957. PMID: 34782410 pubmed.ncbi.nlm.nih.gov/34782410/.
BACK TO TOPReview Date: 3/31/2024
Reviewed By: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School at Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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06/01/2025
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