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Malabsorption

Malabsorption involves problems with the body's ability to take in (absorb) nutrients from food.

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Causes

Many diseases can cause malabsorption. Most often, malabsorption involves problems absorbing certain sugars, fats, proteins, or vitamins. It can also involve an overall problem with absorbing food.

Problems or damage to the small intestine that may lead to problems absorbing important nutrients. These include:

Enzymes produced by the pancreas help absorb fats and other nutrients. A decrease of these enzymes makes it harder to absorb fats and certain nutrients. Problems with the pancreas may be caused by:

Some of the other causes of malabsorption include:

Symptoms

In children, current weight or rate of weight gain is often much lower than that of other children of similar age and sex. This is called failure to thrive. The child may not grow and develop normally.

Adults may also have failure to thrive, with weight loss, muscle wasting, weakness, and even problems thinking.

Changes in the stools are often present, but not always.

Changes in the stools may include:

Exams and Tests

Your health care provider will do an exam. Tests that may be done include:

Treatment

Treatment depends on the cause and is aimed at relieving symptoms and ensuring the body receives enough nutrients.

A high-calorie diet may be tried. It should supply:

If needed, injections of some vitamins and minerals or special growth factors will be given. Those with damage to the pancreas may need to take pancreatic enzymes. Your provider will prescribe these if necessary.

Medicines to slow down the normal movement of the intestine can be tried. This may allow food to remain in the intestine longer.

If the body is not able to absorb enough nutrients, total parenteral nutrition (TPN) is tried. It will help you or your child get nutrition from a special formula through a vein in the body. Your provider will select the right amount of calories and TPN solution. Sometimes, you can also eat and drink while getting nutrition from TPN.

Outlook (Prognosis)

The outlook depends on what is causing the malabsorption.

Possible Complications

Long-term malabsorption can result in:

When to Contact a Medical Professional

Contact your provider if you have symptoms of malabsorption.

Prevention

Prevention depends on the condition causing malabsorption.

Related Information

Failure to thrive
Cystic fibrosis
Lactose intolerance
Celiac disease – sprue
Whipple disease
Biliary atresia
Bassen-Kornzweig syndrome
Pernicious anemia
Giardia infection
Hookworm infection

References

Högenauer C, Hammer HF. Maldigestion and malabsorption. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 104.

Semrad CE. Approach to the patient with diarrhea and malabsorption. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 131.

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Review Date: 5/6/2022  

Reviewed By: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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