Metastases to the liver; Metastatic liver cancer; Liver cancer - metastatic; Colorectal cancer - liver metastases; Colon cancer - liver metastases; Esophageal cancer - liver metastases; Lung cancer - liver metastases; Melanoma - liver metastases
Liver metastases refer to cancer that has spread to the liver from somewhere else in the body.
Liver metastases are not the same as cancer that starts in the liver, which is called hepatocellular carcinoma.
Almost any cancer can spread to the liver. Cancers that can spread to the liver include:
The risk for cancer spreading to the liver depends on the location (site) of the original cancer. A liver metastasis may be present when the original (primary) cancer is diagnosed or it may occur months or years after the primary tumor is removed.
In some cases, there are no symptoms. When symptoms occur, they may include:
Tests that may be done to diagnose liver metastases include:
Treatment depends on:
Types of treatments that may be used are described below.
When the tumor is only in one or a few areas of the liver, the cancer may be removed with surgery.
When the cancer has spread to the liver and other organs, whole-body (systemic) chemotherapy is usually used. The type of chemotherapy used depends on the original type of cancer.
When the cancer has only spread in the liver, systemic chemotherapy may still be used.
Chemoembolization is a type of chemotherapy to one area. A thin tube called a catheter is inserted into an artery in the groin. The catheter is threaded into the artery in the liver. Cancer-killing medicine is sent through the catheter. Then another medicine is sent through the catheter to block blood flow to the part of the liver with the tumor. This "starves" the cancer cells.
How well you do depends on the location of the original cancer and how much it has spread to the liver or anywhere else. In rare cases, surgery to remove the liver tumors leads to a cure. This is usually only possible when there are a limited number of tumors in the liver.
In most cases, cancer that has spread to the liver cannot be cured. People whose cancer has spread to the liver often die of their disease. However, treatments may help shrink tumors, improve life expectancy, and relieve symptoms.
Complications are often the result of tumors spreading to a large area of the liver.
They can include:
Anyone who has had a type of cancer that can spread to the liver should be aware of the signs and symptoms listed above, and call the doctor if any of these develop.
Early detection of some types of cancer may prevent the spread of these cancers to the liver.
Lamps LW. Liver: Tumors and tumorlike conditions. In: Goldblum JR, Lamps LW, McKenney JK, Myers JL, eds. Rosai and Ackerman’s Surgical Pathology. 11th ed. Philadelphia, PA: Elsevier; 2018:chap 20.
Mahvi DA. Mahvi DM. Liver metastases. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 58.BACK TO TOP
Review Date: 1/25/2022
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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