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Thrombocytopenia

Low platelet count - thrombocytopenia

Thrombocytopenia means there is an abnormally low amount of platelets. Platelets are parts of the blood that help blood to clot. This condition is sometimes associated with abnormal bleeding.

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Causes

Thrombocytopenia is often divided into 3 major causes of low platelets:

Your bone marrow may not make enough platelets if you have any of the following conditions:

Use of certain medicines may also lead to a low production of platelets in the bone marrow. The most common example is chemotherapy treatment for cancer.

The following health situations cause a low number of platelets:

Symptoms

You may not have any symptoms. Or you may have general symptoms, such as:

Other symptoms depend on the cause.

Exams and Tests

Your health care provider will perform a physical exam and ask about your medical history and symptoms. The following tests may be done:

Other tests that may help diagnose this condition include bone marrow aspiration or biopsy.

Treatment

Treatment depends on the cause of the condition. In some cases, a transfusion of platelets may be required to stop or prevent bleeding.

Outlook (Prognosis)

The outcome depends on the disorder causing the low platelet counts.

Possible Complications

Severe bleeding (hemorrhage) is the main complication. Bleeding may occur in the brain or gastrointestinal tract.

When to Contact a Medical Professional

Contact your provider if you experience unexplained bleeding or bruising.

Prevention

Prevention depends on the specific cause.

Related Information

Immune thrombocytopenic purpura (ITP)
Drug-induced thrombocytopenia
Thrombotic thrombocytopenic purpura
Essential thrombocythemia
Hypersplenism
Gastrointestinal bleeding
Vomiting blood
Black or tarry stools

References

Abrams CS. Thrombocytopenia. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 158.

Branchford BR, Samelson-Jones BJ, Flood VH. Platelet and blood vessel disorders. In: Kliegman RM, St. Geme JW, Blum NJ, eds. Nelson Textbook of Pediatrics. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 533.

Warkentin TE. Thrombocytopenia caused by hypersplenism, platelet destruction, or surgery/hemodilution. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 130.

Zeller MP, Ning S, Arnold DM, Gabe C. Diseases of platelet number: immune thrombocytopenia, neonatal alloimmune thrombocytopenia, and posttransfusion purpura. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 129.

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Review Date: 3/31/2024  

Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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