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Low blood sodium

Hyponatremia; Dilutional hyponatremia; Euvolemic hyponatremia; Hypervolemic hyponatremia; Hypovolemic hyponatremia

Low blood sodium is a condition in which the sodium level in the blood is lower than normal. The medical name of this condition is hyponatremia.

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Causes

Sodium is found mostly in the body fluids outside the cells. Sodium is an electrolyte (mineral). It is very important for maintaining blood pressure. Sodium is also needed for nerves, muscles, and other body tissues to work properly.

When the amount of sodium in fluids outside cells drops below normal, water moves into the cells. This causes the cells to swell with too much water. Brain cells are especially sensitive to swelling, and this causes many of the symptoms of low blood sodium.

With hyponatremia, the imbalance of water to sodium is caused by one of three conditions:

• Euvolemic hyponatremia -- total body water increases, but the body's sodium content stays the same
• Hypervolemic hyponatremia -- both sodium and water content in the body increase, but the water gain is greater
• Hypovolemic hyponatremia -- water and sodium are both lost from the body, but the sodium loss is greater

Low blood sodium can be caused by:

• Burns that affect a large area of the body
• Diarrhea
• Diuretic medicines (water pills), which increase urine output and loss of sodium through the urine
• Heart failure
• Kidney diseases
• Cirrhosis (advanced liver disease)
• Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
• Sweating
• Vomiting

Symptoms

Common symptoms include:

• Confusion, irritability, restlessness
• Convulsions
• Fatigue
• Headache
• Loss of appetite
• Muscle weakness, spasms, or cramps
• Nausea, vomiting

Exams and Tests

Your health care provider will perform a complete physical examination and ask about your symptoms. Blood and urine tests will be done.

Lab tests that can confirm and help diagnose low sodium include:

• Comprehensive metabolic panel (includes blood sodium, normal range is 135 to 145 mEq/L, or 135 to 145 mmol/L)
• Blood osmolality
• Urine osmolality
• Urine sodium (normal level is 20 mEq/L in a random urine sample, and 40 to 220 mEq per day for a 24-hour urine test)

Treatment

The cause of low blood sodium must be diagnosed and treated. If cancer is the cause of the condition, then radiation, chemotherapy, or surgery to remove the tumor may correct the sodium imbalance.

Other treatments depend on the specific type of hyponatremia.

Treatments may include:

• Fluids through a vein (IV)
• Medicines to relieve symptoms
• Limiting water intake

Outlook (Prognosis)

Outcome depends on the condition that is causing the problem. Hyponatremia that occurs in less than 48 hours (acute hyponatremia), is more dangerous than hyponatremia that develops slowly over time. When blood sodium level falls slowly over days or weeks (chronic hyponatremia), the brain cells have time to adjust and swelling may be minimal.

Possible Complications

In severe cases, low blood sodium can lead to:

• Decreased consciousness, hallucinations or coma
• Brain herniation
• Death

When to Contact a Medical Professional

When your body's sodium level drops too much, it can be a life-threatening emergency. Call your provider right away if you have symptoms of this condition.

Prevention

Treating the condition that is causing hyponatremia can help.

If you play sports or do other vigorous activity, drink fluids such as sports drinks that contain electrolytes to keep your body's sodium level in a healthy range.

Related Information

Electrolytes
Antidiuretic hormone blood test
Fluid imbalance
Lung cancer - small cell
Pancreatic cancer
Prostate cancer
Hodgkin lymphoma
Central nervous system
Hypothyroidism
Psychosis
Acute
Meningitis
Comprehensive metabolic panel

References

Dell KM. Fluid, electrolytes, and acid-base homeostasis. In: Martin RJ, Fanaroff AA, Walsh MC, eds. Fanaroff and Martin's Neonatal-Perinatal Medicine. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 92.

Pasco J. Electrolyte disturbances. In: Cameron P, Little M, Mitra B, Deasy C, eds. Textbook of Adult Emergency Medicine. 5th ed. Philadelphia, PA: Elsevier; 2020:chap 12.2

Verbalis JG. Disorders of water balance. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 15.

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Review Date: 6/12/2023  

Reviewed By: Jacob Berman, MD, MPH, Clinical Assistant Professor of Medicine, Division of General Internal Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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