Aspirin (Rectal route)

Pronunciation:

AS-pir-in

Brand Names:

Pms-Asa Suppository Adult
Pms-Asa Suppository Children
Supasa

Dosage Forms:

Suppository

Classifications:

Therapeutic—

Analgesic

Pharmacologic—

NSAID

Chemical—

Salicylate, Aspirin

Uses of This Medicine:

Aspirin suppository is used to relieve minor aches, pains, and headache and to reduce fever.

This medicine is available as an over-the-counter (OTC) product.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of aspirin suppository in children younger than 12 years of age. Safety and efficacy have not been established.

Older adults—

No information is available on the relationship of age to the effects of aspirin suppository in geriatric patients.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Abrocitinib
Defibrotide
Dichlorphenamide
Influenza Virus Vaccine, Live
Ketorolac

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose
Aceclofenac
Acemetacin
Acenocoumarol
Acetazolamide
Alclometasone
Aldosterone
Alipogene Tiparvovec
Alteplase, Recombinant
Amcinonide
Amikacin
Amiloride
Amineptine
Amitriptyline
Amitriptylinoxide
Amoxapine
Amphotericin B
Amtolmetin Guacil
Anagrelide
Anisindione
Apixaban
Ardeparin
Argatroban
Bacitracin
Beclomethasone
Bemetizide
Bemiparin
Benazepril
Bendroflumethiazide
Benzthiazide
Betamethasone
Betrixaban
Bivalirudin
Brinzolamide
Bromfenac
Budesonide
Bufexamac
Bumetanide
Caplacizumab-yhdp
Capreomycin
Captopril
Celecoxib
Certoparin
Chlorothiazide
Chlorpropamide
Chlorthalidone
Choline Salicylate
Ciclesonide
Cilostazol
Cisplatin
Citalopram
Clobetasol
Clobetasone
Clocortolone
Clomipramine
Clonixin
Clopamide
Clopidogrel
Cortisone
Curcumin
Cyclopenthiazide
Cyclosporine
Cyclothiazide
Dabigatran Etexilate
Dalteparin
Danaparoid
Deflazacort
Desipramine
Desirudin
Desmopressin
Desonide
Desoximetasone
Desvenlafaxine
Dexamethasone
Dexibuprofen
Dexketoprofen
Diazoxide
Dibenzepin
Diclofenac
Dicumarol
Diflorasone
Diflucortolone
Diflunisal
Difluprednate
Digoxin
Dipyrone
Dorzolamide
Dothiepin
Doxepin
Droxicam
Duloxetine
Edoxaban
Emtricitabine
Enalapril
Enalaprilat
Enoxaparin
Eplerenone
Eptifibatide
Escitalopram
Ethacrynic Acid
Etodolac
Etofenamate
Etoricoxib
Etozolin
Felbinac
Fenoprofen
Fepradinol
Feprazone
Feverfew
Floctafenine
Flucloronide
Fludrocortisone
Flufenamic Acid
Flumethasone
Flunisolide
Fluocinolone
Fluocinonide
Fluocortin
Fluocortolone
Fluorometholone
Fluoxetine
Flurandrenolide
Flurbiprofen
Fluticasone
Fluvoxamine
Fondaparinux
Foscarnet
Fosinopril
Fosphenytoin
Furosemide
Gentamicin
Ginkgo
Glimepiride
Glipizide
Glyburide
Gossypol
Halcinonide
Halobetasol
Heparin
Hydrochlorothiazide
Hydrocortisone
Hydroflumethiazide
Ibrutinib
Ibuprofen
Imipramine
Indapamide
Indomethacin
Inotersen
Kanamycin
Ketoprofen
Lepirudin
Levomilnacipran
Lisinopril
Lithium
Lofepramine
Lornoxicam
Loteprednol
Loxoprofen
Lumiracoxib
Macimorelin
Meclofenamate
Medrysone
Mefenamic Acid
Melitracen
Meloxicam
Melphalan
Metformin
Methazolamide
Methotrexate
Methyclothiazide
Methylprednisolone
Metolazone
Milnacipran
Moexipril
Mometasone
Morniflumate
Nabumetone
Nadroparin
Naproxen
Nateglinide
Nefazodone
Neomycin
Nepafenac
Netilmicin
Nicorandil
Niflumic Acid
Nimesulide
Nimesulide Beta Cyclodextrin
Nortriptyline
Opipramol
Oxaprozin
Oxyphenbutazone
Paramethasone
Parecoxib
Parnaparin
Paromomycin
Paroxetine
Pemetrexed
Pentosan Polysulfate Sodium
Pentoxifylline
Perindopril
Phenindione
Phenprocoumon
Phenylbutazone
Phenytoin
Piketoprofen
Piracetam
Piretanide
Piroxicam
Plazomicin
Polythiazide
Potassium Citrate
Pranoprofen
Prasugrel
Prednicarbate
Prednisolone
Prednisone
Proglumetacin
Propyphenazone
Proquazone
Protein C
Protriptyline
Quinapril
Quinethazone
Ramipril
Repaglinide
Reteplase, Recombinant
Reviparin
Rimexolone
Rivaroxaban
Rofecoxib
Salicylic Acid
Salsalate
Selumetinib
Sertraline
Sodium Salicylate
Spectinomycin
Spirapril
Spironolactone
Streptomycin
Sulindac
Sulodexide
Tacrolimus
Tenofovir Alafenamide
Tenofovir Disoproxil Fumarate
Tenoxicam
Tianeptine
Tiaprofenic Acid
Ticagrelor
Ticlopidine
Tinzaparin
Tirofiban
Tobramycin
Tolazamide
Tolbutamide
Tolfenamic Acid
Tolmetin
Torsemide
Trandolapril
Trazodone
Treprostinil
Triamcinolone
Triamterene
Trichlormethiazide
Trimipramine
Turmeric
Valdecoxib
Valproic Acid
Vancomycin
Varicella Virus Vaccine, Live
Venlafaxine
Vilazodone
Vortioxetine
Warfarin
Xipamide

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acebutolol
Atenolol
Betaxolol
Bisoprolol
Carteolol
Carvedilol
Celiprolol
Delapril
Esmolol
Imidapril
Labetalol
Levobunolol
Metipranolol
Metoprolol
Nadolol
Nebivolol
Nitroglycerin
Oxprenolol
Penbutolol
Pindolol
Probenecid
Propranolol
Sotalol
Streptokinase
Tamarind
Temocapril
Tenecteplase
Timolol

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Chicken pox or
Flu—Should not be used in patients who are recovering from these conditions.

Proper Use of This Medicine:

Use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

Follow the instructions on the medicine label if you are using this medicine without a prescription.

To use the suppository:

Remove the suppository from plastic packet.
Lie down on your side and use your finger to push the suppository well up into the rectum.
Remain lying down for about 15 minutes to keep the suppository from coming out before it melts.
Make sure to wash your hands with soap and water before and after inserting this medicine.

Tell your doctor if you drink 3 or more alcoholic drinks every day. Drinking alcoholic beverages while taking this medicine may increase your risk of stomach bleeding.

Dosing—

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For rectal dosage form (suppository):
- For minor aches and pains:
  - Adults and children 12 years of age and older—1 suppository inserted into your rectum every 4 hours. Do not use for more than 10 days.
  - Children younger than 12 years of age—Use and dose must be determined by your doctor.

Missed dose—

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—

You may store the suppositories in the refrigerator, but do not freeze them.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using This Medicine:

It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

Using this medicine during late pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

Aspirin can cause a rare but serious illness called Reye's syndrome in children and teenagers. Call you doctor right away if your child has behavior changes along with nausea and vomiting while using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or non-prescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known: Nausea and vomiting; seizures

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Last Updated: 4/24/2024

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