Netarsudil and latanoprost (Ophthalmic route)

Pronunciation:

ne-TAR-soo-dil, la-TAN-oh-prost

Brand Names:

  • Rocklatan

Dosage Forms:

  • Solution

Classifications:

Therapeutic—

Antiglaucoma

Pharmacologic—

Prostaglandin

Uses of This Medicine:

Netarsudil and latanoprost combination eye drops is used alone or together with other medicines to lower pressure inside the eye that is caused by open-angle glaucoma or ocular (eye) hypertension.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of netarsudil and latanoprost combination eye drops in the pediatric population. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of netarsudil and latanoprost combination eye drops in the elderly.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Aphakia (no lens in the eyes) or
  • Eye inflammation (eg, iritis or uveitis), history of or
  • Herpes simplex eye infection, history of or
  • Patients with torn artificial lenses—Use with caution. May make these conditions worse.
  • Eye infection or inflammation, active—Should not be used in patients with this condition.

Proper Use of This Medicine:

Use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use if for a longer time than your doctor ordered. To do so may increase the chance of side effects.

To use the eye drops:

  • Wash your hands with soap and water before and after you use this medicine.
  • Tilt the head back. Press your finger gently on the skin just beneath the lower eyelid and pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 1 or 2 minutes to allow the medicine to be absorbed by the eye.
  • To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed. Serious damage to the eye and possible loss of vision may result from using contaminated eye medicines.
  • You should not use the eye drops if you have contact lenses in your eyes. Remove your contact lenses before you use this medicine. Wait at least 15 minutes after you use the medicine before putting the contact lenses back in.
  • If you will be using netarsudil/latanoprost eye drops with other eye medicines, use them at least 5 minutes apart from each other.

Dosing—

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For ophthalmic solution dosage form (eye drops):
    • For glaucoma or ocular hypertension:
      • Adults—One drop in the affected eye(s) once a day in the evening.
      • Children—Use and dose must be determined by your doctor.

Missed dose—

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

You may also store it at room temperature to higher temperatures for up to 14 days when travelling. Keep the opened bottle until the expiration date.

Precautions While Using This Medicine:

It is very important that your eye doctor (ophthalmologist) check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.

If itching, redness, swelling, or other signs of eye or eyelid irritation occur, check with your doctor right away.

This medicine contains latanoprost, which can cause the iris (colored part) of your treated eye to become more brown in color. This is more likely to happen if you have blue-brown, gray-brown, green-brown, or yellow-brown eyes. You may notice this change usually within several months or years from the start of treatment. You may also have darkening of the eyelid skin color or longer, thicker, and darker eyelashes. These changes to the iris, eyelid, and lashes may be permanent even if you stop using this medicine. However, any of these changes will affect only the eye being treated. Check with your doctor if you have any concerns about this.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
Bloody eye
blurred vision or any other change in vision
eye redness, irritation, or pain
redness of the eye
Rare
Body aches or pain
burning and stinging of the eye
change in color vision
chills
cough
diarrhea
difficulty in breathing
difficulty seeing at night
difficulty swallowing
dizziness
dry eye
ear congestion
excessive tearing
eyelid discomfort, swelling, or redness
fast heartbeat
fever
general feeling of discomfort or illness
headache
hives, itching, skin rash
increased sensitivity of the eyes to sunlight
joint pain
loss of appetite
loss of voice
nausea
painful irritation of the clear front part of the eye
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
runny or stuffy nose
shivering
sneezing
sore throat
sweating
tightness in the chest
trouble sleeping
unusual tiredness or weakness
vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Eye itching
pain and discomfort at the instillation site
Less common
Increase in brown color in the colored part of the eye
redness of the white part of the eyes or the inside of the eyelids
Rare
Back pain
crusting in the corner of the eye
difficulty in moving
discoloration of the white part of the eye
feeling of having something in the eye
joint pain or swelling
muscle pain, cramps, or stiffness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 9/5/2019

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

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The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
All rights reserved.

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