Macimorelin (Oral route)

Pronunciation:

ma-si-moe-REL-in

Brand Names:

Macrilen

Uses of This Medicine:

Macimorelin is used for the diagnosis of adult growth hormone deficiency (AGHD).

This medicine is to be given only by or under the supervision of a doctor.

Before Using This Medicine:

In deciding to use a diagnostic test, any risks of the test must be weighed against the good it will do. This is a decision you and your doctor will make. Also, other things may affect test results. For this test, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of macimorelin in the pediatric population. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of macimorelin in the elderly.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this diagnostic test, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Receiving this diagnostic test with any of the following medicines is not recommended. Your doctor may decide not to use this diagnostic test or change some of the other medicines you take.

Bepridil
Cisapride
Dronedarone
Fluconazole
Ketoconazole
Levoketoconazole
Mesoridazine
Pimozide
Piperaquine
Posaconazole
Saquinavir
Sparfloxacin
Terfenadine
Thioridazine
Ziprasidone

Receiving this diagnostic test with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir
Adagrasib
Alclometasone
Alfuzosin
Amcinonide
Amiodarone
Amisulpride
Amitriptyline
Anagrelide
Apomorphine
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Asenapine
Aspirin
Astemizole
Atazanavir
Atropine
Azithromycin
Beclomethasone
Bedaquiline
Betamethasone
Budesonide
Buprenorphine
Buserelin
Carbamazepine
Ceritinib
Chloroquine
Chlorpromazine
Ciclesonide
Ciprofloxacin
Citalopram
Clarithromycin
Clobetasol
Clobetasone
Clocortolone
Clofazimine
Clomipramine
Clonidine
Clothiapine
Clozapine
Cortisone
Crizotinib
Cyclobenzaprine
Dabrafenib
Dasatinib
Deflazacort
Degarelix
Delamanid
Desipramine
Deslorelin
Desonide
Desoximetasone
Deutetrabenazine
Dexamethasone
Dexmedetomidine
Diflorasone
Diflucortolone
Difluprednate
Disopyramide
Dofetilide
Dolasetron
Domperidone
Donepezil
Doxepin
Droperidol
Ebastine
Efavirenz
Encorafenib
Entrectinib
Enzalutamide
Eribulin
Erythromycin
Escitalopram
Famotidine
Fedratinib
Felbamate
Fexinidazole
Fingolimod
Flecainide
Flucloronide
Fludrocortisone
Flumethasone
Flunisolide
Fluocinolone
Fluocinonide
Fluocortin
Fluocortolone
Fluorometholone
Fluoxetine
Flurandrenolide
Fluticasone
Formoterol
Foscarnet
Fosphenytoin
Fostemsavir
Galantamine
Gatifloxacin
Gemifloxacin
Gepirone
Glasdegib
Gonadorelin
Goserelin
Granisetron
Halcinonide
Halofantrine
Haloperidol
Histrelin
Hydrocortisone
Hydroquinidine
Hydroxychloroquine
Hydroxyzine
Ibutilide
Iloperidone
Imipramine
Indomethacin
Inotuzumab Ozogamicin
Insulin
Insulin Aspart, Recombinant
Insulin Bovine
Insulin Degludec
Insulin Detemir
Insulin Glulisine
Insulin Lispro, Recombinant
Itraconazole
Ivabradine
Ivosidenib
Lapatinib
Lefamulin
Lenvatinib
Leuprolide
Levodopa
Levofloxacin
Lofexidine
Loteprednol
Lumacaftor
Lumefantrine
Mavacamten
Mefloquine
Methadone
Methotrimeprazine
Methylprednisolone
Metronidazole
Mifepristone
Mirtazapine
Mitotane
Mizolastine
Mobocertinib
Mometasone
Moricizine
Moxifloxacin
Nafarelin
Nelfinavir
Nilotinib
Norfloxacin
Octreotide
Ofloxacin
Olanzapine
Omaveloxolone
Ondansetron
Osilodrostat
Osimertinib
Oxaliplatin
Ozanimod
Pacritinib
Paliperidone
Panobinostat
Papaverine
Paroxetine
Pasireotide
Pazopanib
Pentamidine
Perphenazine
Phenobarbital
Phenytoin
Pimavanserin
Pipamperone
Pitolisant
Ponesimod
Prednicarbate
Prednisolone
Prednisone
Primidone
Probucol
Procainamide
Prochlorperazine
Promethazine
Propafenone
Propylthiouracil
Protriptyline
Quetiapine
Quinidine
Quinine
Quizartinib
Ranolazine
Relugolix
Ribociclib
Rifampin
Rimexolone
Risperidone
Ritonavir
Selpercatinib
Sertindole
Sevoflurane
Siponimod
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Somatostatin
Sorafenib
Sotalol
St John's Wort
Sulpiride
Sultopride
Sunitinib
Tacrolimus
Tamoxifen
Telaprevir
Telavancin
Telithromycin
Tetrabenazine
Tolterodine
Toremifene
Trazodone
Triamcinolone
Triclabendazole
Trimipramine
Triptorelin
Vandetanib
Vardenafil
Vemurafenib
Venlafaxine
Vilanterol
Vinflunine
Voclosporin
Voriconazole
Vorinostat
Zotepine
Zuclopenthixol

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this diagnostic test. Make sure you tell your doctor if you have any other medical problems, especially:

Glucocorticoid (steroid) deficiency or
Sex hormone deficiency or
Thyroid deficiency—Your doctor may tell you to replace these missing hormones before starting treatment with this medicine.

Heart rhythm problem (eg, QT prolongation)—Used with caution. May make this condition worse.

Lesion in the brain (eg, hypothalamus)—Adult growth hormone deficiency caused by this condition may cause a false negative result. Repeat testing may be needed.

Proper Use of This Medicine:

A healthcare provider will give you this medicine in a hospital or clinic. You should drink all the medicine within 30 seconds.

Follow all instructions you are given for your scan or procedure. Your doctor may tell you not to eat or drink anything at least 8 hours before your test.

Precautions While Using This Medicine:

It is very important that your doctor check your progress to make sure that this medicine is working properly and to check for unwanted effects.

Do not use a growth hormone medicine for at least 1 week before receiving this medicine.

Do not use armodafinil (Nuvigil®), bosentan (Tracleer®), carbamazepine (Tegretol®), efavirenz (Sustiva®), enzalutamide (Xtandi®), etravirine (Intelence®), mitotane (Lysodren®), modafinil (Provigil®), phenytoin (Dilantin®), rifampin (Rifadin®, Rimactane®), rufinamide (Banzel®), or St. John’s wort together with macimorelin. These medicines may decrease the amount of macimorelin in the blood, which may cause a false positive result to adult growth hormone deficiency test. Your doctor may tell you to stop taking these medicines for a certain period of time before using macimorelin.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common: Slow heartbeat

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common: Body aches or pain; change in taste; chills; cough; diarrhea; difficulty in breathing; dizziness; ear congestion; feeling hot; fever; headache; hunger; increased sweating; loss of taste; loss of voice; muscle aches; nasal congestion; nausea; runny nose; sneezing; sore throat; stuffy or runny nose; unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Last Updated: 11/16/2023

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.