Iohexol (Intravenous route)

Pronunciation:

eye-oh-HEX-ol

Warnings:

Intravenous route(Solution)

Warning: Risks with Inadvertent Intrathecal AdministrationOmnipaque(R) injection, 140 and 350 mg iodine/mL: Inadvertent intrathecal administration may cause death, convulsions/seizures, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, rhabdomyolysis, hyperthermia, and brain edema .

Uses of This Medicine:

Iohexol injection is used to help diagnose or find problems in the brain, back, heart, head, blood vessels, and other parts of the body. It is an iodinated contrast agent. Contrast agents are used to create a clear picture of the different parts of the body during certain medical procedures (eg, CT scans).

This medicine is to be given only by or under the supervision of a doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of iohexol in children. Some pediatric patients with certain medical conditions (eg, asthma, heart failure, kidney problems) may have more unwanted side effects which may require caution in patients receiving iohexol.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of iohexol in the elderly. However, elderly patients are more likely to have unwanted side effects which may require caution and an adjustment in the dose for patients receiving iohexol.

Breast-feeding—

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Amiodarone
  • Atenolol
  • Betaxolol
  • Bisoprolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Esmolol
  • Labetalol
  • Levobunolol
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Oxprenolol
  • Penbutolol
  • Pindolol
  • Practolol
  • Propranolol
  • Sotalol
  • Timolol

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse or
  • Heart or blood vessel disease—Iohexol injection should be used with caution in these patients.
  • Asthma—Use with caution. May increase risk of having allergic reactions.
  • Congestive heart failure or
  • Dehydration or
  • Diabetes or
  • Kidney disease or
  • Multiple myeloma (cancer of plasma cells) or
  • Paraproteinemia (high amount of paraprotein in the blood)—May increase risk of having kidney failure.
  • Heart or blood vessel disease or
  • Hypertension (high blood pressure) or
  • Hyperthyroidism (overactive thyroid) or
  • Kidney disease, severe or
  • Liver disease or
  • Pheochromocytoma (adrenal problem) or
  • Sickle cell anemia (inherited blood disorder)—Use with caution. May make these conditions worse.

Proper Use of This Medicine:

A doctor or other trained health professional will give you this medicine in a hospital. It is given through a needle placed into a vein.

Your doctor may also give you medicines (eg, allergy medicine, steroids) to prevent allergic reactions.

Drink extra fluids so you will pass more urine while you are receiving this medicine. This may help prevent kidney problems.

Precautions While Using This Medicine:

It is very important that your doctor check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

This medicine may cause a heart attack. Tell your doctor right away if you have chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness, or coughing up blood.

Severe kidney problems may occur after receiving this medicine. Tell your doctor right away if you have the following symptoms after receiving the medicine: agitation, confusion, decreased urine output, dizziness, headache, muscle twitching, rapid weight gain, or swelling of the face, ankles, or hands.

This medicine may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have a skin rash, itching, shortness of breath, sweating, swelling of the face, tongue, and throat, or tightness in the chest after you receive this medicine.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or a skin rash, sores or ulcers on the skin, or fever or chills with this medicine.

Make sure your doctor knows if you have had an allergic reaction to any dye or medicine given during a test or procedure.

While using this medicine, you may be exposed to radiation. Talk with your doctor if you have concerns about this.

Make sure any doctor or dentist who treats you knows that you are using iohexol injection. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. You should not receive iohexol injection together with a steroid medicine into your spinal cord.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common
Arm, back, or jaw pain
chest pain, discomfort, tightness, or heaviness
difficulty breathing
dizziness
fainting
fast, slow, or irregular heartbeat
nausea
sweating
swelling in the throat
Rare
Blurred vision
confusion
dilated neck veins
dizziness or lightheadedness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
extreme tiredness or weakness
fast, pounding, or irregular heartbeat or pulse
feeling cold
feeling of constant movement of self or surroundings
fever
irregular breathing
pale skin
seizures
sensation of spinning
swelling of the face, fingers, feet, or lower legs
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness
weight gain
Incidence not known
Agitation
black, tarry stools
blistering, peeling, or loosening of the skin
bloating
bluish color of the fingernails, lips, skin, palms, or nail beds
changes in skin color, pain, tenderness, or swelling of the foot or leg
chest pain or discomfort
chills
constipation
cough
darkened urine
decreased urine output
diarrhea
difficulty swallowing
discouragement
drowsiness
feeling sad or empty
headache
hives, itching, skin rash
indigestion
irritability
joint or muscle pain
lack of appetite
loss of consciousness
loss of interest or pleasure
lower back or side pain
mood or mental changes
muscle twitching
nervousness
pain or discomfort in the arms, jaw, back, or neck
painful or difficult urination
pains in the stomach, side, or abdomen, possibly radiating to the back
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rapid weight gain
red, irritated eyes
red skin lesions, often with a purple center
seeing, hearing, or feeling things that are not there
sensitivity to heat
sore throat
sores, ulcers, or white spots in the mouth or on the lips
stiff neck
temporary vision loss
throat irritation or tightness
trouble concentrating
trouble sleeping
unusual bleeding or bruising
unusual drowsiness, dullness, or feeling of sluggishness
vomiting
weight loss
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
Bad, unusual, or unpleasant (after) taste
change in taste
Rare
Anxiety
belching
cold sweats
dry mouth
heartburn
increased hunger
indigestion
nightmares
redness of the skin
runny nose
shakiness
sleepiness or unusual drowsiness
slurred speech
sneezing
stomach discomfort, upset, or pain
stuffy nose
uncontrolled eye movements

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 6/18/2019

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

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The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
All rights reserved.

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