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Tedizolid (Intravenous route)

Pronunciation:

te-DIZ-oh-lid FOS-fate

Brand Names:

  • Sivextro

Dosage Forms:

  • Powder for Solution

Classifications:

Therapeutic—

Antibacterial

Chemical—

Oxazolidinone

Uses of This Medicine:

Tedizolid injection is used to treat acute bacterial skin and skin structure infections (ABSSSI). It belongs to the class of drugs called antibiotics. Tedizolid works by killing bacteria or preventing their growth.

This medicine is to be given only by or under the direct supervision of your doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of tedizolid injection in children younger than 12 years of age. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tedizolid injection in the elderly.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cholera Vaccine, Live

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Diarrhea—Use with caution. May make this condition worse.
  • Neutropenia (low white blood cell count)—Tedizolid may not work as well in patients with this condition.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins. The medicine must be given slowly, so the needle will have to remain in place for at least 1 hour.

This medicine should come with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Precautions While Using This Medicine:

It is very important that your doctor check your or your child's progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to check for any unwanted effects.

This medicine may cause diarrhea, and in some cases it can be severe. It may also occur 2 months or more after you or your child stop receiving this medicine. If you or your child have diarrhea that continues or gets worse, check with your doctor. Do not take any medicine to treat diarrhea without checking first with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common
Bluish color of the skin
blurred vision
chest tightness
diarrhea
dizziness
fast, slow, pounding, or irregular heartbeat or pulse
fever
headache
hives or welts, itching, or skin rash
hoarseness
irritation
itching of the vagina or genitals
joint pain, stiffness, or swelling
nervousness
pain or tenderness of the skin
pale skin
pounding in the ears
redness of the skin
severe stomach cramps and pain
sore mouth or tongue
stomach tenderness
swelling of the eyelids, face, lips, hands, legs, or feet
thick, white vaginal discharge with mild or no odor
trouble breathing or swallowing
unusual bleeding or bruising
unusual tiredness or weakness
watery or severe diarrhea, which may also be bloody
white patches in the mouth or on the tongue
Incidence not known
Black, tarry stools
blood in the urine or stools
chills
cough
lower back or side pain
painful or difficult urination
pinpoint red spots on the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Nausea
Less common
Bleeding, blistering, burning, discoloration of the skin, infection, itching, lumps, numbness, pain, redness, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
double vision
feeling of warmth
feeling that you cannot keep your eyes open
increased sensitivity of the eyes to light
redness of the face, neck, arms, and occasionally, upper chest
seeing floating spots before the eyes
sore neck, shoulders, or back
sore, tired, burning, or itching eyes
trouble concentrating
trouble sleeping
vomiting
watery or dry eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 3/30/2022
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