Sotalol (Intravenous route)

Pronunciation:

SOE-ta-lol

Dosage Forms:

Solution

Warnings:

Intravenous route(Solution)

Sotalol can cause life threatening ventricular tachycardia associated with QT interval prolongation. To minimize the risk of drug induced arrythmia, initiate or uptitrate intravenous sotalol in a facility that can provide continuous electrocardiographic monitoring and cardiac resuscitation. Do not initiate intravenous sotalol therapy if the baseline QTc is longer than 450 ms. If the QTc prolongs to 500 ms or greater, reduce the dose or discontinue .

Classifications:

Therapeutic—

Antiarrhythmic, Group III

Pharmacologic—

Beta-Adrenergic Blocker, Nonselective

Uses of This Medicine:

Sotalol injection is used to treat life-threatening heart rhythm problem called ventricular arrhythmia. It is also used to treat heart rhythm problems called atrial fibrillation or atrial flutter.

Sotalol is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and at a regular rhythm.

This medicine is to be given only by or under the direct supervision of your doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of sotalol injection in the pediatric population. Safety and efficacy have not been established.

Older adults—

No information is available on the relationship of age to the effects of sotalol injection in elderly patients. However, elderly patients are more likely to have age-related kidney disease, which may require an adjustment in the dose for patients receiving sotalol injection.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Bepridil
Cisapride
Dronedarone
Fingolimod
Grepafloxacin
Levoketoconazole
Levomethadyl
Mesoridazine
Pimozide
Piperaquine
Saquinavir
Sparfloxacin
Terfenadine
Thioridazine
Vernakalant
Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acecainide
Acetazolamide
Adagrasib
Albuterol
Alfuzosin
Amiloride
Amiodarone
Amisulpride
Amitriptyline
Amoxapine
Anagrelide
Apomorphine
Arformoterol
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Artemether
Asenapine
Astemizole
Atazanavir
Azithromycin
Azosemide
Bambuterol
Bedaquiline
Bemetizide
Bendroflumethiazide
Benzthiazide
Bitolterol
Broxaterol
Bumetanide
Buprenorphine
Buserelin
Canrenoate
Ceritinib
Chloral Hydrate
Chloroquine
Chlorpromazine
Chlorthalidone
Ciprofloxacin
Citalopram
Clarithromycin
Clenbuterol
Clofazimine
Clomipramine
Clonidine
Clopamide
Clothiapine
Clozapine
Colterol
Crizotinib
Cyclobenzaprine
Cyclothiazide
Dabrafenib
Darunavir
Dasatinib
Degarelix
Delamanid
Desipramine
Deslorelin
Deutetrabenazine
Dexmedetomidine
Dibenzepin
Digoxin
Diltiazem
Disopyramide
Dofetilide
Dolasetron
Domperidone
Donepezil
Doxepin
Droperidol
Ebastine
Efavirenz
Eliglustat
Encainide
Encorafenib
Enflurane
Entrectinib
Epinephrine
Eribulin
Erythromycin
Escitalopram
Ethacrynic Acid
Etozolin
Etrasimod
Famotidine
Felbamate
Fenoldopam
Fenoterol
Fenquizone
Fexinidazole
Flecainide
Fluconazole
Fluoxetine
Formoterol
Foscarnet
Fosphenytoin
Fostemsavir
Furosemide
Galantamine
Gatifloxacin
Gemifloxacin
Gepirone
Glasdegib
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Halothane
Hexoprenaline
Histrelin
Hydrochlorothiazide
Hydroflumethiazide
Hydroquinidine
Hydroxychloroquine
Hydroxyzine
Ibutilide
Iloperidone
Imipramine
Indacaterol
Indapamide
Indecainide
Inotuzumab Ozogamicin
Iobenguane I 131
Iohexol
Isoetharine
Isoflurane
Isradipine
Itraconazole
Ivabradine
Ivosidenib
Ketoconazole
Lacosamide
Lapatinib
Lefamulin
Lenvatinib
Leuprolide
Levalbuterol
Levofloxacin
Lidocaine
Lidoflazine
Lofexidine
Lopinavir
Lumefantrine
Macimorelin
Mannitol
Mefloquine
Metaproterenol
Methadone
Methotrimeprazine
Metolazone
Metronidazole
Mexiletine
Mifepristone
Mirtazapine
Mizolastine
Mobocertinib
Moricizine
Moxifloxacin
Nafarelin
Nelfinavir
Nilotinib
Norfloxacin
Nortriptyline
Octreotide
Ofloxacin
Olanzapine
Olodaterol
Ondansetron
Osilodrostat
Osimertinib
Oxaliplatin
Oxymetazoline
Ozanimod
Pacritinib
Paliperidone
Panobinostat
Papaverine
Paroxetine
Pasireotide
Pazopanib
Pentamidine
Perphenazine
Phenobarbital
Pimavanserin
Pipamperone
Pirbuterol
Piretanide
Pitolisant
Polythiazide
Ponesimod
Posaconazole
Prilocaine
Primidone
Probucol
Procainamide
Procaterol
Prochlorperazine
Promethazine
Propafenone
Protriptyline
Quetiapine
Quinethazone
Quinidine
Quinine
Quizartinib
Ranolazine
Relugolix
Reproterol
Ribociclib
Rimiterol
Risperidone
Ritodrine
Ritonavir
Rivastigmine
Salmeterol
Selpercatinib
Sertindole
Sertraline
Sevoflurane
Siponimod
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Sorafenib
Spiramycin
Spironolactone
Sulfamethoxazole
Sulpiride
Sultopride
Sunitinib
Tacrolimus
Tamoxifen
Telaprevir
Telavancin
Telithromycin
Terbutaline
Tetrabenazine
Ticrynafen
Tocainide
Tolterodine
Toremifene
Torsemide
Trazodone
Tretoquinol
Triamterene
Trichlormethiazide
Triclabendazole
Trifluoperazine
Trimethoprim
Trimipramine
Triptorelin
Tulobuterol
Vandetanib
Vardenafil
Vemurafenib
Venlafaxine
Verapamil
Vilanterol
Vinflunine
Voclosporin
Voriconazole
Vorinostat
Xipamide
Zolmitriptan
Zotepine
Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abarelix
Acarbose
Aceclofenac
Acemetacin
Albiglutide
Alogliptin
Amtolmetin Guacil
Aspirin
Bromfenac
Bufexamac
Bunazosin
Canagliflozin
Celecoxib
Chlorpropamide
Choline Salicylate
Clonixin
Dapagliflozin
Dexibuprofen
Dexketoprofen
Diclofenac
Diflunisal
Dipyrone
Doxazosin
Droxicam
Dulaglutide
Empagliflozin
Ertugliflozin
Etodolac
Etofenamate
Etoricoxib
Exenatide
Felbinac
Fenoprofen
Fepradinol
Feprazone
Floctafenine
Flufenamic Acid
Flurbiprofen
Glimepiride
Glipizide
Glyburide
Ibuprofen
Indomethacin
Insulin Aspart, Recombinant
Insulin Degludec
Insulin Detemir
Insulin Glargine, Recombinant
Insulin Glulisine
Insulin Human Inhaled
Insulin Human Isophane (NPH)
Insulin Human Regular
Insulin Lispro, Recombinant
Ketoprofen
Ketorolac
Linagliptin
Liraglutide
Lixisenatide
Lornoxicam
Loxoprofen
Lumiracoxib
Meclofenamate
Mefenamic Acid
Meloxicam
Metformin
Methyldopa
Miglitol
Morniflumate
Moxisylyte
Nabumetone
Naproxen
Nateglinide
Nepafenac
Niflumic Acid
Nimesulide
Nimesulide Beta Cyclodextrin
Oxaprozin
Oxyphenbutazone
Parecoxib
Phenoxybenzamine
Phentolamine
Phenylbutazone
Piketoprofen
Pioglitazone
Piroxicam
Pramlintide
Pranoprofen
Prazosin
Proglumetacin
Propyphenazone
Proquazone
Repaglinide
Rofecoxib
Rosiglitazone
Salicylic Acid
Salsalate
Saxagliptin
Sitagliptin
Sodium Salicylate
St John's Wort
Sulindac
Tamsulosin
Tenoxicam
Terazosin
Tiaprofenic Acid
Tolazamide
Tolbutamide
Tolfenamic Acid
Tolmetin
Trimazosin
Urapidil
Valdecoxib
Vildagliptin

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Angina (severe chest pain) or
Heart attack, recent or
Heart disease or
Heart failure, history of or
Heart rhythm problem (eg, QT prolongation) or
Hypomagnesemia (low magnesium levels in the blood) or
Hypotension (low blood pressure)—Use with caution. May make these conditions worse.

Asthma or
Bradycardia (slow heartbeat), without a pacemaker or
Bronchospasm or
Cardiogenic shock (shock caused by heart attack) or
Heart block, without a pacemaker or
Heart failure, uncontrolled or
Heart rhythm problem (eg, long QT syndrome) or
Hypokalemia (low potassium levels in the blood) or
Kidney disease, severe or
Sick sinus syndrome (type of abnormal heart rhythm), without pacemaker—Should not be used in patients with these conditions.

Diabetes or
Hyperthyroidism (overactive thyroid) or
Hypoglycemia (low blood sugar)—Use with caution. May cover up some of the symptoms of these diseases, such as a fast heartbeat.

Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins.

Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions While Using This Medicine:

It is very important that your doctor check your progress while you are receiving this medicine to make sure the medicine is working properly. Blood, urine, and ECG tests will be needed to check for unwanted effects.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. These symptoms are more likely to occur when you begin using this medicine, or when the dose is increased. Getting up slowly may help.

Sotalol may cause heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort, dilated neck veins, extreme fatigue, irregular breathing, an irregular heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, unusual tiredness or weakness, or weight gain.

This medicine may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are receiving this medicine.

This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common: Blurred vision; chest pain, discomfort, or tightness; confusion; difficult or labored breathing; dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position; fast, irregular, pounding, or racing heartbeat or pulse; increased sweating; slow or irregular heartbeat; sweating; swelling; trouble breathing; unusual tiredness or weakness

Less common: Arm, back, or jaw pain; body aches or pain; chest heaviness; chills; cold hands and feet; cough; decreased urine output; diarrhea; difficulty with breathing; difficulty with speaking; dilated neck veins; dizziness; double vision; ear congestion; fainting; fever; general feeling of discomfort or illness; headache; inability to move the arms, legs, or facial muscles; inability to speak; irregular breathing; joint pain; loss of appetite; loss of voice; muscle aches and pains; nausea; nervousness; noisy breathing; pounding in the ears; runny or stuffy nose; shivering; slow speech; sneezing; sore throat; swelling of the face, fingers, feet, or lower legs; trouble sleeping; vomiting; weight gain

Incidence not known: Black, tarry stools; bleeding gums; blood in the urine or stools; blue lips and fingernails; coughing that sometimes produces a pink frothy sputum; difficult, fast, or noisy breathing; increased sweating; painful or difficult urination; pale skin; pinpoint red spots on the skin; sores, ulcers, or white spots on the lips or in the mouth; swelling in the legs and ankles; swollen glands; unusual bleeding or bruising

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose: Anxiety; blurred vision; chest pain or discomfort; cold sweats; confusion; cool, pale skin; dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position; depression; fast, pounding, or irregular heartbeat or pulse; increased hunger; nightmares; seizures; shakiness; slow or irregular heartbeat; slurred speech; sweating; unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common: Abnormal ejaculation; back pain; bloated feeling; burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; decreased appetite; decreased interest in sexual intercourse; excess air or gas in the stomach or intestines; full feeling; inability to have or keep an erection; loss in sexual ability, desire, drive, or performance; muscle or bone pain; passing gas; rash; stomach distension

Incidence not known: Hair loss or thinning of the hair; itching skin; loss or thinning of the hair; muscle aches, cramps, pains, or stiffness; pain, itching, burning, swelling, or a lump under your skin where the needle is placed; severe sunburn; swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Last Updated: 4/24/2024

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