Plerixafor (Subcutaneous route)

Pronunciation:

pler-IX-a-fore

Brand Names:

  • Mozobil

Dosage Forms:

  • Solution

Classifications:

Therapeutic—

Hematopoietic

Uses of This Medicine:

Plerixafor injection is used together with a granulocyte-colony stimulating factor or G-CSF (eg, filgrastim, pegfilgrastim) to mobilize hematopoietic stem cells (HSC) for collection and transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).

This medicine is to be given only by or under the direct supervision of your doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of plerixafor injection in the pediatric population. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of plerixafor injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving plerixafor.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bone marrow cancer or other bone marrow problems (eg, leukemia) or
  • Enlarged spleen or
  • Leukocytosis (high white blood cell count) or
  • Thrombocytopenia (low blood platelet count)—Use with caution. May make these conditions worse.
  • Kidney disease, moderate or severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine in a medical facility. It is given as a shot under your skin.

Plerixafor injection should be started after you have received a G-CSF medicine (eg, filgrastim, pegfilgrastim) for 4 days.

Precautions While Using This Medicine:

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control during treatment and for 1 week after the last dose. If a pregnancy occurs while you are using this medicine, tell your doctor right away.

This medicine may enlarge your spleen, which could possibly burst. Check with your doctor right away if you have pain in the upper left part of your stomach or at the tip of your left shoulder.

Tell your doctor right away if you have a slow heartbeat, severe, unusual tiredness or weakness, cold sweats, confusion, or dizziness, faintness, or lightheadedness when getting up from a lying or sitting position after you get the injection.

This medicine may cause a serious allergic reaction, called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

This medicine may cause diarrhea, nausea, vomiting, or stomach pain in some patients. Ask your doctor or nurse about other ways to control these side effects.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Bleeding gums
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
collection of blood under the skin
coughing up blood
deep, dark purple bruise
difficulty in breathing or swallowing
dizziness
feeling of heat
flushing, redness of the skin
hard lump
headache
hives or welts, itching, skin rash
increased menstrual flow or vaginal bleeding
irritation
nosebleeds
pain
paralysis
prolonged bleeding from cuts
red or black, tarry stools
red or dark brown urine
swelling
unusually warm skin
Rare
Chills
cold sweats
confusion
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
fainting
fast heartbeat
swelling around the eyes
tightness in the chest
weakness
Incidence not known
Cough
feeling of fullness
pain in the left upper stomach or around the left shoulder
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
stomach pain
unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Bloated feeling
diarrhea
difficulty in moving
excess air or gas in the stomach or bowels
muscle pain or stiffness
nausea
pain in the joints
passing gas
trouble sleeping
vomiting
Less common
Belching
bone pain
difficulty having a bowel movement
dry mouth
general feeling of discomfort or illness
heartburn
increased sweating
indigestion
pressure in the stomach
stomach discomfort or upset
swelling of the abdominal or stomach area
Incidence not known
Abnormal dreams and nightmares

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 9/5/2019

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

All rights reserved.


The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
All rights reserved.

A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.