Fluconazole (Intravenous route)

Pronunciation:

floo-KON-a-zole

Brand Names:

Diflucan IV
Diflucan

Dosage Forms:

Solution

Classifications:

Therapeutic—

Antifungal

Chemical—

Triazole

Uses of This Medicine:

Fluconazole injection is used to treat serious fungal or yeast infections, including oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of the stomach], and infections that may occur in different parts of the body), or fungal (cryptococcal) meningitis. This medicine works by killing the fungus or yeast, or preventing its growth.

Fluconazole injection is also used to prevent candidiasis in patients having bone marrow transplants, who receive cancer or radiation treatment.

This medicine is to be given only by or under the direct supervision of a doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of fluconazole injection in children 6 months to 13 years of age. However, safety and efficacy have not been established in children younger than 6 months of age.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fluconazole injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving fluconazole injection.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Alfuzosin
Amiodarone
Aripiprazole
Aripiprazole Lauroxil
Artemether
Atazanavir
Bedaquiline
Bepridil
Buprenorphine
Cisapride
Citalopram
Clarithromycin
Clozapine
Crizotinib
Dabrafenib
Dasatinib
Dofetilide
Domperidone
Donepezil
Dronedarone
Ebastine
Eliglustat
Encorafenib
Entrectinib
Erythromycin
Escitalopram
Flibanserin
Glasdegib
Granisetron
Haloperidol
Iloperidone
Itraconazole
Ivabradine
Ivosidenib
Ketoconazole
Lapatinib
Levoketoconazole
Levomethadyl
Lomitapide
Lopinavir
Lumefantrine
Macimorelin
Mavacamten
Mefloquine
Mesoridazine
Methadone
Mifepristone
Mirtazapine
Mobocertinib
Nelfinavir
Nilotinib
Ondansetron
Osilodrostat
Panobinostat
Pazopanib
Pimavanserin
Pimozide
Piperaquine
Pitolisant
Propafenone
Quetiapine
Quinidine
Quinine
Ranolazine
Ribociclib
Ritonavir
Saquinavir
Selpercatinib
Solifenacin
Sorafenib
Sparfloxacin
Sunitinib
Tacrolimus
Tamoxifen
Telaprevir
Telithromycin
Thioridazine
Toremifene
Trazodone
Vandetanib
Vardenafil
Vemurafenib
Vilanterol
Vinflunine
Voclosporin
Voriconazole
Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abrocitinib
Acalabrutinib
Acenocoumarol
Adagrasib
Ajmaline
Alfentanil
Alprazolam
Amisulpride
Amitriptyline
Amoxapine
Anagrelide
Anisindione
Apixaban
Apomorphine
Aprepitant
Aprindine
Arsenic Trioxide
Asenapine
Atorvastatin
Avanafil
Avapritinib
Avatrombopag
Azilsartan
Azilsartan Medoxomil
Azithromycin
Belzutifan
Benzhydrocodone
Bosutinib
Bretylium
Brexpiprazole
Brigatinib
Brotizolam
Budesonide
Buserelin
Buspirone
Carbamazepine
Carvedilol
Celecoxib
Ceritinib
Cerivastatin
Chloral Hydrate
Chloroquine
Chlorpromazine
Cilostazol
Ciprofloxacin
Clobazam
Clofazimine
Clomipramine
Clopidogrel
Clothiapine
Cobimetinib
Codeine
Colchicine
Conivaptan
Cyclobenzaprine
Cyclosporine
Daridorexant
Darifenacin
Darunavir
Deflazacort
Degarelix
Delamanid
Desipramine
Deslorelin
Deutetrabenazine
Dexlansoprazole
Dexmedetomidine
Diazepam
Dibenzepin
Dicumarol
Dihydrocodeine
Dihydroergotamine
Disopyramide
Dolasetron
Doxepin
Doxorubicin
Doxorubicin Hydrochloride Liposome
Droperidol
Efavirenz
Elacestrant
Eletriptan
Elexacaftor
Elvitegravir
Enflurane
Eplerenone
Ergoloid Mesylates
Ergonovine
Ergotamine
Eribulin
Etravirine
Everolimus
Famotidine
Fedratinib
Felbamate
Felodipine
Fentanyl
Finerenone
Fingolimod
Flecainide
Fluoxetine
Flurbiprofen
Fluticasone
Fluvastatin
Formoterol
Fosaprepitant
Foscarnet
Fosphenytoin
Galantamine
Gatifloxacin
Gemifloxacin
Gepirone
Gliclazide
Glimepiride
Glipizide
Glyburide
Gonadorelin
Goserelin
Halothane
Hexobarbital
Histrelin
Hydrocodone
Hydroquinidine
Hydroxychloroquine
Hydroxyzine
Ibrexafungerp
Ibrutinib
Ibuprofen
Ibutilide
Ifosfamide
Imipramine
Indinavir
Infigratinib
Inotuzumab Ozogamicin
Irbesartan
Isavuconazonium Sulfate
Isoflurane
Isradipine
Ivacaftor
Lansoprazole
Larotrectinib
Lefamulin
Lemborexant
Lenvatinib
Leuprolide
Levofloxacin
Levomilnacipran
Lidoflazine
Lofexidine
Lorcainide
Lorlatinib
Lornoxicam
Lovastatin
Lumateperone
Lurasidone
Lurbinectedin
Macitentan
Maraviroc
Meloxicam
Meperidine
Mephenytoin
Mephobarbital
Meprobamate
Methotrexate
Methotrimeprazine
Methylergonovine
Metronidazole
Midazolam
Midostaurin
Milnacipran
Mitapivat
Mizolastine
Moricizine
Moxifloxacin
Nafarelin
Naloxegol
Naproxen
Nevirapine
Nifedipine
Nisoldipine
Nitrofurantoin
Norfloxacin
Nortriptyline
Octreotide
Ofloxacin
Olanzapine
Olaparib
Omaveloxolone
Omeprazole
Osimertinib
Ospemifene
Oxaliplatin
Oxycodone
Ozanimod
Paclitaxel
Paliperidone
Palovarotene
Pantoprazole
Papaverine
Parecoxib
Paritaprevir
Paroxetine
Pasireotide
Pemigatinib
Pentamidine
Pentazocine
Perphenazine
Pexidartinib
Phenindione
Phenobarbital
Phenprocoumon
Phenytoin
Pipamperone
Pirmenol
Piroxicam
Ponesimod
Posaconazole
Prajmaline
Pralsetinib
Primidone
Probucol
Procainamide
Prochlorperazine
Proguanil
Promethazine
Protriptyline
Quizartinib
Rabeprazole
Rifabutin
Rimegepant
Risperidone
Ruxolitinib
Selumetinib
Sertindole
Sertraline
Sevoflurane
Sildenafil
Simeprevir
Simvastatin
Siponimod
Sirolimus
Sirolimus Protein-Bound
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Sonidegib
Sotalol
Sparsentan
Spiramycin
Sufentanil
Sulfamethoxazole
Sulpiride
Sultopride
Tazemetostat
Telavancin
Temsirolimus
Terfenadine
Tetrabenazine
Tezacaftor
Theophylline
Ticagrelor
Tilidine
Tipranavir
Tofacitinib
Tolbutamide
Tolterodine
Tolvaptan
Torsemide
Tramadol
Triazolam
Triclabendazole
Trifluoperazine
Trimethoprim
Trimipramine
Triptorelin
Ubrogepant
Ulipristal
Valdecoxib
Venetoclax
Venlafaxine
Verapamil
Vinblastine
Vincristine
Vincristine Sulfate Liposome
Vinorelbine
Vorinostat
Vortioxetine
Warfarin
Zanubrutinib
Zidovudine
Zolmitriptan
Zolpidem
Zotepine
Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amlodipine
Atevirdine
Losartan
Nicardipine
Prednisone
Ramelteon
Rifampin
Rifapentine
Rivaroxaban
Suvorexant
Tretinoin
Trimetrexate

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Electrolyte problems (mineral imbalance) or
Heart disease—Use with caution. These conditions may increase your chance of having heart rhythm problems and make the effects of this medicine worse.

Heart rhythm problems (eg, QT prolongation) or
Liver disease—Use with caution. May make these conditions worse.

Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of This Medicine:

A nurse or other trained health professional will give you or your child this medicine. This medicine is given through a needle placed in one of your veins.

Your doctor will give you or your child a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions While Using This Medicine:

It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

If your or your child's symptoms do not improve, or if they become worse, check with your doctor. You may need to use this medicine for several months before your infection gets better.

You or your child should not use erythromycin (Ery-Tab®), pimozide (Orap®), or quinidine (Cardioquin®) while receiving this medicine because of the risk of unwanted side effects.

Using this medicine for a long time or using it too much while you are pregnant (especially during the first trimester) can harm your unborn baby. Use an effective form of birth control during treatment with this medicine and for at least 1 week after the last dose. If you think you have become pregnant while using this medicine, tell your doctor right away.

This medicine may rarely cause serious liver problems. Check with your doctor right away if you or your child have stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, or yellow eyes or skin.

This medicine may rarely cause a serious type of allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you or your child have a rash, itching, swelling of the face, tongue, and throat, trouble breathing, or chest pain after you receive the medicine.

Serious skin reactions can occur in certain people during treatment with this medicine. Check with your doctor right away if you or your child start having a skin rash, itching, or any other skin changes while you are using this medicine.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem including QT prolongation.

This medicine may cause adrenal gland problems. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare: Chest tightness; chills; clay-colored stools; cough; dark urine; diarrhea; difficulty with swallowing; dizziness; fast heartbeat; fever; headache; hives, itching, or skin rash; large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs; light-colored stools; loss of appetite; nausea and vomiting; puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; stomach pain, continuing; unpleasant breath odor; unusual tiredness or weakness; upper right abdominal or stomach pain; vomiting of blood; yellow eyes and skin

Incidence not known: Black, tarry stools; blistering, peeling, or loosening of the skin; chest pain or discomfort; decreased urine; dry mouth; fainting; hoarseness; increased thirst; irregular or slow heart rate; joint or muscle pain; loss of bladder control; lower back or side pain; mood changes; muscle pain or cramps; muscle spasm or jerking of all extremities; numbness or tingling in the hands, feet, or lips; painful or difficult urination; pale skin; red skin lesions, often with a purple center; red, irritated eyes; seizures; sore throat; sores, ulcers, or white spots in the mouth or on the lips; sudden loss of consciousness; swollen glands; unusual bleeding or bruising

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose: Fearfulness, suspiciousness, or other mental changes; seeing, hearing, or feeling things that are not there

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common: Acid or sour stomach; belching; change in taste or bad, unusual, or unpleasant (after) taste; heartburn; indigestion; stomach discomfort or upset

Incidence not known: Hair loss or thinning of the hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Last Updated: 11/16/2023

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