Pronunciation:

proe-PRAN-oh-lol

Brand Names:

• Inderal

Dosage Forms:

• Solution

Classifications:

Therapeutic—

Cardiovascular Agent

Pharmacologic—

Beta-Adrenergic Blocker, Nonselective

Uses of This Medicine:

Propranolol injection is used to control fast heartbeats and abnormal heart rhythms .

This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and at a regular rhythm .

This medicine is available only with your doctor's prescription .

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of propranolol injection in the pediatric population. Safety and efficacy have not been established .

Older adults—

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of propranolol injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment of dosage in patients receiving propranolol injection .

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Rizatriptan
• Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abametapir
• Albuterol
• Bupivacaine
• Bupivacaine Liposome
• Bupropion
• Capmatinib
• Ceritinib
• Clonidine
• Crizotinib
• Darunavir
• Desvenlafaxine
• Diatrizoate
• Diltiazem
• Dronedarone
• Epinephrine
• Escitalopram
• Eslicarbazepine Acetate
• Fedratinib
• Fenoldopam
• Fexinidazole
• Fingolimod
• Fluoxetine
• Formoterol
• Haloperidol
• Indacaterol
• Iobenguane I 131
• Iohexol
• Lacosamide
• Lercanidipine
• Levalbuterol
• Lidocaine
• Mefloquine
• Mepivacaine
• Olodaterol
• Oxymetazoline
• Pixantrone
• Ponesimod
• Prilocaine
• Rivastigmine
• Salmeterol
• Simeprevir
• Siponimod
• Sparsentan
• Terbutaline
• Venlafaxine
• Verapamil
• Vilanterol
• Zileuton

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acarbose
• Aceclofenac
• Acemetacin
• Acetyldigoxin
• Albiglutide
• Alfuzosin
• Alogliptin
• Amtolmetin Guacil
• Aspirin
• Bromfenac
• Bufexamac
• Bunazosin
• Canagliflozin
• Celecoxib
• Chlorpromazine
• Chlorpropamide
• Cholestyramine
• Choline Salicylate
• Cimetidine
• Clonixin
• Dapagliflozin
• Deslanoside
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Digitoxin
• Digoxin
• Dihydroergotamine
• Dipyrone
• Doxazosin
• Droxicam
• Dulaglutide
• Empagliflozin
• Ergotamine
• Ertugliflozin
• Etodolac
• Etofenamate
• Etoricoxib
• Exenatide
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Flecainide
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Fluvoxamine
• Glimepiride
• Glipizide
• Glyburide
• Ibuprofen
• Indomethacin
• Insulin Aspart, Recombinant
• Insulin Degludec
• Insulin Detemir
• Insulin Glargine, Recombinant
• Insulin Glulisine
• Insulin Human Inhaled
• Insulin Human Isophane (NPH)
• Insulin Human Regular
• Insulin Lispro, Recombinant
• Ketoprofen
• Ketorolac
• Linagliptin
• Liraglutide
• Lixisenatide
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Metformin
• Metildigoxin
• Miglitol
• Morniflumate
• Moxisylyte
• Nabumetone
• Naproxen
• Nateglinide
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Phenoxybenzamine
• Phentolamine
• Phenylbutazone
• Piketoprofen
• Pioglitazone
• Piroxicam
• Pramlintide
• Pranoprofen
• Prazosin
• Proglumetacin
• Propyphenazone
• Proquazone
• Quinidine
• Repaglinide
• Rifapentine
• Rofecoxib
• Rosiglitazone
• Salicylic Acid
• Salsalate
• Saxagliptin
• Sitagliptin
• Sodium Salicylate
• St John's Wort
• Sulindac
• Tamsulosin
• Tenoxicam
• Terazosin
• Tiaprofenic Acid
• Tolazamide
• Tolbutamide
• Tolfenamic Acid
• Tolmetin
• Trimazosin
• Urapidil
• Valdecoxib
• Vildagliptin

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Tobacco

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina (severe chest pain)—May provoke chest pain if stopped too quickly .

• Asthma or
• Bradycardia (slow heartbeat) or
• Heart block or
• Heart failure—Should not use in patients with these conditions .

• Diabetes or
• Hyperthyroidism (overactive thyroid) or
• Hypoglycemia (low blood sugar)—May cover up some of the signs and symptoms of these diseases, such as a fast heartbeat .

• Kidney disease or
• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body .

• Lung disease (e.g., bronchitis, emphysema)—May cause difficulty with breathing in patients with this condition .

• Wolff-Parkinson-White syndrome (rare heart condition)—May cause a very slow heartbeat in patients with this condition .

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins .

Precautions While Using This Medicine:

Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor .

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Blurred vision

chest pain or discomfort

confusion

decreased urine output

dilated neck veins

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

extreme fatigue

irregular breathing

lightheadedness, dizziness, or fainting

shortness of breath

slow or irregular heartbeat

sweating

swelling of face, fingers, feet, or lower legs

tightness in chest

troubled breathing

unusual tiredness or weakness

weight gain

wheezing

Rare

Blisters, hives, or itching

fever and chills

general feeling of discomfort or illness

hair loss

headaches

muscle or joint pain

skin rash

sore throat

swollen glands

Incidence not determined

Abdominal pain, usually after eating a meal

abdominal tenderness

black, tarry stools

blood in urine

bloody nose

bloody stools

body aches or pain

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

congestion

constipation

cough

decreased awareness or responsiveness

diarrhea

difficult or labored breathing

dryness or soreness of throat

general feeling of tiredness or weakness

heavier menstrual periods

hoarseness

lower back or side pain

mimicry of speech or movements

mutism

nausea

negativism

no blood pressure or pulse

noisy breathing

painful or difficult urination

paleness or cold feeling in fingertips and toes

peculiar postures or movements, mannerisms, or grimacing

pinpoint red or purple spots on skin

rectal bleeding

reddened skin

runny nose

severe sleepiness

sores on the skin

sores, ulcers, or white spots on lips or in mouth

stopping of heart

tender, swollen glands in neck

tingling or pain in fingers or toes when exposed to cold

trouble in swallowing

unconsciousness

unusual bleeding or bruising

voice changes

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

Decreased interest in sexual intercourse

dry eyes

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

pain of penis on erection

skin irritation or rash, including rash that looks like psoriasis

thinning of hair

Incidence not determined

Confusion about identity, place, and time

crying

depersonalization

disturbed color perception

double vision

dysphoria

euphoria

halos around lights

loss of strength or energy

loss of vision

mental depression

muscle weakness

night blindness

overbright appearance of lights

paranoia

quick to react or overreact emotionally

rapidly changing moods

seeing, hearing, or feeling things that are not there

short-term memory loss

sleeplessness

trouble sleeping

tunnel vision

unable to sleep

unusual drowsiness, dullness, or feeling of sluggishness

vivid dreams

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.