Meprobamate and aspirin (Oral route)

Pronunciation:

me-proe-BAM-ate, AS-pir-in

Brand Names:

Equagesic
Micrainin

Classifications:

Pharmacologic—

NSAID

Chemical—

Carbamate

Uses of This Medicine:

Meprobamate and aspirin combination is used to relieve pain, anxiety, and tension in certain disorders or diseases.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Do not give a medicine containing aspirin to a child or teenager with a fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing this with your child's doctor. This is very important because aspirin may cause a serious illness called Reye's syndrome in children or teenagers with fever caused by a virus infection, especially flu or chickenpox. Children who do not have a virus infection may also be more sensitive to the effects of aspirin (contained in this combination medicine), especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating. This may increase the chance of side effects during treatment.

Older adults—

Elderly people may be especially sensitive to the effects of meprobamate and aspirin. This may increase the chance of side effects during treatment.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Abrocitinib
Defibrotide
Dichlorphenamide
Influenza Virus Vaccine, Live
Ketorolac

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose
Aceclofenac
Acemetacin
Acenocoumarol
Acetazolamide
Alclometasone
Aldosterone
Alfentanil
Alipogene Tiparvovec
Alprazolam
Alteplase, Recombinant
Amcinonide
Amikacin
Amiloride
Amineptine
Amitriptyline
Amitriptylinoxide
Amobarbital
Amoxapine
Amphotericin B
Amtolmetin Guacil
Anagrelide
Anisindione
Apixaban
Aprobarbital
Ardeparin
Argatroban
Bacitracin
Beclomethasone
Bemetizide
Bemiparin
Benazepril
Bendroflumethiazide
Benzhydrocodone
Benzthiazide
Betamethasone
Betrixaban
Bivalirudin
Brinzolamide
Bromazepam
Bromfenac
Bromopride
Budesonide
Bufexamac
Bumetanide
Buprenorphine
Butabarbital
Butalbital
Butorphanol
Calcium Oxybate
Cannabidiol
Cannabis
Caplacizumab-yhdp
Capreomycin
Captopril
Carbinoxamine
Carisoprodol
Celecoxib
Certoparin
Cetirizine
Chloral Hydrate
Chlordiazepoxide
Chlorothiazide
Chlorpropamide
Chlorthalidone
Chlorzoxazone
Choline Salicylate
Ciclesonide
Cilostazol
Cisplatin
Citalopram
Clobazam
Clobetasol
Clobetasone
Clocortolone
Clomipramine
Clonazepam
Clonixin
Clopamide
Clopidogrel
Clorazepate
Codeine
Cortisone
Curcumin
Cyclopenthiazide
Cyclosporine
Cyclothiazide
Dabigatran Etexilate
Dalteparin
Danaparoid
Dantrolene
Daridorexant
Deflazacort
Desipramine
Desirudin
Desmopressin
Desonide
Desoximetasone
Desvenlafaxine
Dexamethasone
Dexibuprofen
Dexketoprofen
Dexmedetomidine
Diazepam
Diazoxide
Dibenzepin
Diclofenac
Dicumarol
Diflorasone
Diflucortolone
Diflunisal
Difluprednate
Digoxin
Dihydrocodeine
Dipyrone
Dorzolamide
Dothiepin
Doxepin
Doxylamine
Droxicam
Duloxetine
Edoxaban
Emtricitabine
Enalapril
Enalaprilat
Enoxaparin
Eplerenone
Eptifibatide
Escitalopram
Esketamine
Eslicarbazepine Acetate
Estazolam
Ethacrynic Acid
Ethchlorvynol
Etodolac
Etofenamate
Etoricoxib
Etozolin
Felbinac
Fenoprofen
Fentanyl
Fepradinol
Feprazone
Feverfew
Flibanserin
Floctafenine
Flucloronide
Fluconazole
Fludrocortisone
Flufenamic Acid
Flumethasone
Flunisolide
Flunitrazepam
Fluocinolone
Fluocinonide
Fluocortin
Fluocortolone
Fluorometholone
Fluoxetine
Flurandrenolide
Flurazepam
Flurbiprofen
Fluticasone
Fluvoxamine
Fondaparinux
Foscarnet
Fosinopril
Fosphenytoin
Fospropofol
Furosemide
Gabapentin
Gabapentin Enacarbil
Gentamicin
Ginkgo
Glimepiride
Glipizide
Glyburide
Gossypol
Halazepam
Halcinonide
Halobetasol
Heparin
Hydrochlorothiazide
Hydrocodone
Hydrocortisone
Hydroflumethiazide
Hydromorphone
Ibrutinib
Ibuprofen
Imipramine
Indapamide
Indomethacin
Inotersen
Kanamycin
Ketamine
Ketazolam
Ketoprofen
Lacosamide
Lemborexant
Lepirudin
Levocetirizine
Levomilnacipran
Levorphanol
Lisinopril
Lithium
Lofepramine
Lofexidine
Lorazepam
Lormetazepam
Lornoxicam
Loteprednol
Loxapine
Loxoprofen
Lumiracoxib
Macimorelin
Magnesium Oxybate
Meclizine
Meclofenamate
Medazepam
Medrysone
Mefenamic Acid
Melitracen
Meloxicam
Melphalan
Meperidine
Mephenesin
Mephobarbital
Metaxalone
Metformin
Methadone
Methazolamide
Methocarbamol
Methohexital
Methotrexate
Methyclothiazide
Methylprednisolone
Metoclopramide
Metolazone
Midazolam
Milnacipran
Moexipril
Mometasone
Morniflumate
Morphine
Morphine Sulfate Liposome
Nabumetone
Nadroparin
Nalbuphine
Naproxen
Nateglinide
Nefazodone
Neomycin
Nepafenac
Netilmicin
Nicorandil
Niflumic Acid
Nimesulide
Nimesulide Beta Cyclodextrin
Nitrazepam
Nortriptyline
Olanzapine
Opipramol
Oxaprozin
Oxazepam
Oxycodone
Oxymorphone
Oxyphenbutazone
Paramethasone
Parecoxib
Parnaparin
Paromomycin
Paroxetine
Pemetrexed
Pentazocine
Pentobarbital
Pentosan Polysulfate Sodium
Pentoxifylline
Periciazine
Perindopril
Phenindione
Phenobarbital
Phenprocoumon
Phenylbutazone
Phenytoin
Piketoprofen
Piracetam
Piretanide
Piroxicam
Plazomicin
Polythiazide
Potassium Citrate
Potassium Oxybate
Pranoprofen
Prasugrel
Prazepam
Prednicarbate
Prednisolone
Prednisone
Pregabalin
Primidone
Proglumetacin
Propofol
Propyphenazone
Proquazone
Protein C
Protriptyline
Quazepam
Quinapril
Quinethazone
Ramipril
Remifentanil
Remimazolam
Repaglinide
Reteplase, Recombinant
Reviparin
Rimexolone
Rivaroxaban
Rofecoxib
Ropeginterferon Alfa-2b-njft
Salicylic Acid
Salsalate
Scopolamine
Secobarbital
Selumetinib
Sertraline
Sodium Oxybate
Sodium Salicylate
Sparsentan
Spectinomycin
Spirapril
Spironolactone
Streptomycin
Sufentanil
Sulindac
Sulodexide
Tacrolimus
Tapentadol
Temazepam
Tenofovir Alafenamide
Tenofovir Disoproxil Fumarate
Tenoxicam
Thiopental
Tianeptine
Tiaprofenic Acid
Ticagrelor
Ticlopidine
Tinzaparin
Tirofiban
Tobramycin
Tolazamide
Tolbutamide
Tolfenamic Acid
Tolmetin
Topiramate
Torsemide
Tramadol
Trandolapril
Trazodone
Treprostinil
Triamcinolone
Triamterene
Triazolam
Trichlormethiazide
Trimipramine
Turmeric
Valdecoxib
Valproic Acid
Vancomycin
Varicella Virus Vaccine, Live
Venlafaxine
Vilazodone
Vortioxetine
Warfarin
Xipamide
Zolpidem
Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acebutolol
Atenolol
Betaxolol
Bisoprolol
Carteolol
Carvedilol
Celiprolol
Delapril
Esmolol
Imidapril
Labetalol
Levobunolol
Metipranolol
Metoprolol
Nadolol
Nebivolol
Nitroglycerin
Oxprenolol
Penbutolol
Pindolol
Probenecid
Propranolol
Sotalol
Streptokinase
Tamarind
Temocapril
Tenecteplase
Timolol

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Alcohol abuse (or history of) or
Drug abuse or dependence (or history of)—Dependence on meprobamate may develop

Anemia or
Stomach ulcer or other stomach problems—Aspirin may make your condition worse

Asthma, allergies, and nasal polyps (history of) or
Kidney disease or
Liver disease—The chance of side effects may be increased.

Epilepsy—The risk of seizures may be increased

Gout—Aspirin may make this condition worse and may also lessen the effects of some medicines used to treat gout

Hemophilia or other bleeding problems—The chance of bleeding may be increased by aspirin

Porphyria—Meprobamate may make the condition worse

Proper Use of This Medicine:

Take this medicine with food or a full glass (8 ounces) of water to lessen stomach irritation.

Do not take this medicine if it has a strong vinegar-like odor. This odor means the aspirin in it is breaking down. If you have any questions about this, check with your health care professional.

Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much meprobamate is taken, it may become habit-forming. Also, taking too much aspirin may cause stomach problems or lead to medical problems because of an overdose.

Dosing—

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Adults—Oral, 1 or 2 tablets three or four times a day, as needed.
Children up to 12 years of age: Use is not recommended.

Storage—

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using This Medicine:

If you will be taking this medicine regularly for a long time:

Your doctor should check your progress at regular visits.
Check with your doctor at least every 4 months to make sure you need to continue taking this medicine.

If you will be taking this medicine in large doses or for a long time, do not stop taking it without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely.

Check the labels of all nonprescription (over-the-counter [OTC]) and prescription medicines you now take. If any contain aspirin or other salicylates (including bismuth subsalicylate [e.g., Pepto-Bismol]), be especially careful. Taking or using any of these medicines while taking this combination medicine containing aspirin may lead to overdose. If you have any questions about this, check with your health care professional.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine.

Stomach problems may be more likely to occur if you drink alcoholic beverages while being treated with this medicine, especially if you are taking the medicine in high doses or for a long time. Check with your doctor if you have any questions about this.

Too much use of this medicine together with certain other medicines may increase the chance of stomach problems. Therefore, do not regularly take this medicine together with any of the following medicines, unless directed to do so by your medical doctor or dentist:

Acetaminophen (e.g., Tylenol)
Diclofenac (e.g., Voltaren)
Diflunisal (e.g., Dolobid)
Etodolac (e.g., Lodine)
Fenoprofen (e.g., Nalfon)
Floctafenine (e.g., Idarac)
Flurbiprofen (oral) (e.g., Ansaid)
Ibuprofen (e.g., Motrin)
Indomethacin (e.g., Indocin)
Ketoprofen (e.g., Orudis)
Ketorolac (e.g., Toradol)
Meclofenamate (e.g., Meclomen)
Mefenamic acid (e.g., Ponstel)
Naproxen (e.g., Naprosyn)
Phenylbutazone (e.g., Butazolidin)
Piroxicam (e.g., Feldene)
Sulindac (e.g., Clinoril)
Tiaprofenic acid (e.g., Surgam)
Tolmetin (e.g., Tolectin)

If you are taking a laxative containing cellulose, do not take it within 2 hours of taking this medicine. Taking these medicines close together may make this medicine less effective by preventing the aspirin (contained in this combination medicine) from being absorbed by your body.

For diabetic patients:

False urine sugar test results may occur if you take 8 or more 325-mg (5-grain) doses of aspirin (contained in this combination medicine) every day for several days in a row. Smaller doses or occasional use of aspirin usually will not affect urine sugar tests. If you have any questions about this, check with your doctor, especially if your diabetes is not well controlled.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests, such as the metyrapone test and the phentolamine test, may be affected by this medicine.

If you plan to have surgery, including dental surgery, do not take aspirin (contained in this combination medicine) for 5 days before the surgery, unless otherwise directed by your medical doctor or dentist. Taking aspirin during this time may cause bleeding problems.

If you think you or someone else may have taken an overdose of this medicine, get emergency help at once. Taking an overdose of this medicine or taking alcohol or other CNS depressants with it may lead to unconsciousness and possibly death. Some signs of an overdose are continuing ringing or buzzing in ears; any hearing loss; severe confusion, drowsiness, or weakness; shortness of breath or slow or troubled breathing; staggering; and slow heartbeat.

This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.

Meprobamate (contained in this combination medicine) may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare: Wheezing, shortness of breath, troubled breathing, or tightness in chest

Symptoms of overdose: Any loss of hearing; bloody urine; confusion (severe); convulsions (seizures); diarrhea (severe or continuing); dizziness or lightheadedness (continuing); drowsiness (severe); fast or deep breathing; hallucinations (seeing, hearing, or feeling things that are not there); headache (severe or continuing); increased sweating; nausea or vomiting (continuing); nervousness or excitement (severe); ringing or buzzing in ears (continuing); slow heartbeat; slurred speech; staggering; stomach pain (severe or continuing); unexplained fever; unusual or uncontrolled flapping movements of the hands, especially in elderly patients; unusual thirst; vision problems; weakness (severe)

Symptoms of overdose in children: Changes in behavior; drowsiness or tiredness (severe); fast or deep breathing

Check with your doctor as soon as possible if any of the following side effects occur:

Rare: Bloody or black, tarry stools; confusion; skin rash, hives, or itching; sore throat and fever; unusual bleeding or bruising; unusual excitement; unusual tiredness or weakness; vomiting of blood or material that looks like coffee grounds

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common: Drowsiness; heartburn or indigestion; nausea with or without vomiting; stomach pain (mild)

Less common: Blurred vision or change in near or distant vision; dizziness or lightheadedness; headache

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

Clumsiness or unsteadiness

confusion

convulsions (seizures)

hallucinations (seeing, hearing, or feeling things that are not there)

increased dreaming

muscle twitching

nausea or vomiting

nervousness or restlessness

nightmares

trembling

trouble in sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Last Updated: 11/16/2023

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