Zanidatamab-hrii (By injection)
Zanidatamab-hrii (zan-i-DAT-a-mab - hrii)
Treats biliary tract cancer (BTC).
Brand Name(s):
Ziihera
There may be other brand names for this medicine.When This Medicine Should Not Be Used:
This medicine is not right for everyone. You should not receive it if you had an allergic reaction to zanidatamab-hrii.How to Use This Medicine:
Injectable
- Your doctor will prescribe your dose and schedule. This medicine is given through an IV placed in a vein. It must be given slowly, so the IV will have to remain in place for at least 120 to 150 minutes.
- You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
- Your doctor will give you other medicines (including allergy medicine, fever medicine, steroid) 30 to 60 minutes before you receive this medicine to help prevent unwanted effects.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Warnings While Using This Medicine:
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. If you can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Use an effective form of birth control during treatment with this medicine and for at least 4 months after your last dose.
- Tell your doctor if you are breastfeeding, or if you have liver disease or heart disease.
- This medicine may cause the following problems:
- Heart problems
- Infusion reactions, which could be severe
- This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain, fever, chills, dizziness, lightheadedness
- Diarrhea, stomach pain, nausea, vomiting
- Rapid weight gain, swelling in your hands, ankles, or feet
- Tiredness, trouble breathing, uneven heartbeat
- Warmth or redness in your face, neck, arms, or upper chest
If you notice these less serious side effects, talk with your doctor:
- Decreased appetite
- Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 2/4/2025