Revumenib (By mouth)
Revumenib (re-VOO-me-nib)
Treats leukemia.
Brand Name(s):
Revuforj
There may be other brand names for this medicine.When This Medicine Should Not Be Used:
This medicine is not right for everyone. Do not use it if you had an allergic reaction to revumenib.How to Use This Medicine:
Tablet
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
- Take this medicine at the same time each day. You may take this medicine on an empty stomach or with a low-fat meal.
- Swallow the tablet whole with a cup of water. Do not cut or chew it.
- If you are unable to swallow the tablet whole:
- Add all the tablets to a clean and dry pill crusher. Screw the top of the pill crusher down until it touches the tablets.
- Turn the cap back and forth to crush the tablets. Repeat until all large tablet pieces are broken up. The crushed tablets should be like the consistency of flour.
- Use 2 teaspoons to measure 10 milliliters (mL) of room temperature water and add it into a small cup. Add the crushed tablets into the small cup with 10 mL water. Tap the pill crusher to make sure no more crushed tablet pieces are left.
- Carefully swirl the cup every 30 seconds to 1 minute for a total of 5 minutes. The mixture should look cloudy.
- Draw up the mixture into a 20 mL syringe. Turn the oral syringe upside down and back multiple times before taking or giving the medicine. Take the mixture within 2 hours of mixing.
- Place the tip of the oral syringe into the mouth against the inside of the cheek. Slowly and gently press down on the plunger. Allow the patient to swallow the medicine. Make sure that no medicine is left in the mouth. The patient should remain sitting up straight or standing for 2 to 3 minutes right after receiving the medicine.
- Rinse the cup with another 10 mL of room temperature water and repeat the steps to swirl and draw up the water, and give the water until no medicine is left in the cup.
- This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
- Missed dose:
- If you miss a dose and it is 12 hours or more until your next regular dose, take the missed dose as soon as possible, and then go back to your regular schedule. If you miss a dose and it is less than 12 hours until your next regular dose, skip the missed dose and take your next dose at the regular time. Do not use extra medicine to make up for a missed dose.
- If you vomit after taking a dose of this medicine, do not take an additional dose. Take your next dose at your usual time.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines can affect how revumenib works. Tell your doctor if you are using any of the following:
- Cobicistat
- Medicine for heart rhythm problems
- Medicine to treat fungus infection (including itraconazole, posaconazole, voriconazole)
Warnings While Using This Medicine:
- This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant within 7 days before starting treatment. Use an effective form of birth control during treatment and for at least 4 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for at least 4 months after the last dose.
- Do not breastfeed during treatment and for 1 week after the last dose.
- Tell your doctor if you have kidney disease, liver disease, heart rhythm problems (including long QT syndrome), heart failure, or electrolyte problems.
- This medicine may cause the following problems:
- Differentiation syndrome, which may be life-threatening
- Heart rhythm problems
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate
- Chest pain, trouble breathing
- Fainting, dizziness, lightheadedness
- Fast, pounding, or uneven heartbeat
- Fever, chills, cough, sore throat, body aches
- Muscle or bone pain
- Rapid weight gain, swelling in your hands, ankles, or feet
- Unusual bleeding or bruising
If you notice these less serious side effects, talk with your doctor:
- Constipation, diarrhea, nausea, vomiting
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 2/4/2025