Lazertinib (By mouth)
Lazertinib (laz-ER-ti-nib)
Treats non-small cell lung cancer (NSCLC).
Brand Name(s):
Lazcluze
There may be other brand names for this medicine.When This Medicine Should Not Be Used:
This medicine is not right for everyone. Do not use it if you had an allergic reaction to lazertinib.How to Use This Medicine:
Tablet
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
- Swallow the tablet whole. Do not crush, cut, or chew it.
- Take this medicine any time before receiving amivantamab, when given on the same day.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Missed dose:
- If you miss a dose and it is less than 12 hours, take the missed dose as soon as possible, and then go back to your regular schedule. If you miss a dose and it is more than 12 hours, skip the missed dose and take your next dose at the regular time. Do not use extra medicine to make up for a missed dose.
- If you vomit after taking a dose of this medicine, do not take an additional dose. Take your next dose at your usual time.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines can affect how lazertinib works. Tell your doctor if you are using efavirenz, itraconazole, midazolam, rifampin, or rosuvastatin.
Warnings While Using This Medicine:
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. If you are woman who can get pregnant, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Use an effective form of birth control during treatment and for 3 weeks after the last dose. Male patients who have female partners should use effective birth control during treatment and for 3 weeks after the last dose.
- Do not breastfeed during treatment and for 3 weeks after the last dose.
- Tell your doctor if you have liver disease or a history of lung or breathing problems.
- This medicine may cause the following problems:
- Blood clots, including deep vein thrombosis, pulmonary embolism
- Lung or breathing problems (including interstitial lung disease, pneumonitis)
- Serious skin reactions (including dermatitis acneiform)
- Eye or vision problems, including keratitis
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Blistering, peeling, red skin rash
- Blurred vision, eye pain or redness, sensitivity of the eye to light
- Fever, chills, cough, chest pain or tightness, trouble breathing
- Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg
- Pain, redness, or swelling around the fingernails
- Rapid weight gain, swelling in your hands, ankles, or feet
- Sudden or severe headache, problems with vision, speech, or walking
- Unusual bleeding or bruising
If you notice these less serious side effects, talk with your doctor:
- Constipation, diarrhea, nausea, vomiting, decreased appetite
- Muscle or joint pain
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet
- Sores or white patches on your lips, mouth, or throat
- Tiredness
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 2/4/2025