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Diroximel fumarate (By mouth)

Diroximel Fumarate (dye-ROX-i-mel FUE-ma-rate)

Treats relapsing forms of multiple sclerosis (MS).

Brand Name(s):

Vumerity

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to diroximel fumarate or dimethyl fumarate.

How to Use This Medicine:

Delayed Release Capsule

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Swallow the delayed-release capsule whole. Do not crush or chew it. Do not sprinkle the contents of the capsule on food.
  • If you take this medicine with food, avoid a high-fat, high-calorie meal or snack. The meal or snack should contain no more than 700 calories and no more than 30 g fat.
  • Your doctor may want you to take some medicine (including non-enteric coated aspirin) 30 minutes before taking this medicine to prevent flushing.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with dimethyl fumarate.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or any type of infection, or a weak immune system.
  • This medicine may cause the following problems:
    • Increased risk of infections, which may be life-threatening, including progressive multifocal leukoencephalopathy (PML) or herpes zoster (shingles)
    • Liver problems, which may lead to liver failure or liver transplant
  • This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Back pain, blurred vision, convulsions, dizziness, fever, headache, tiredness
  • Change in how much or how often you urinate, lower back or side pain, painful or difficult urination
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fever or chills, cough, sore throat, body aches

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea
  • Warmth or redness in your face, neck, arms, or upper chest

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 12/4/2023

 

 
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