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Dolutegravir/lamivudine (By mouth)

Dolutegravir (doe-loo-TEG-ra-vir), Lamivudine (la-MIV-ue-deen)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to dolutegravir or lamivudine.

Your doctor will tell you how much medicine to use. Do not use more than directed.
Do not stop using this medicine without checking first with your doctor. If you stop the medicine even briefly, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is low so you do not run out.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Do not use this medicine together with dofetilide.
Some medicines can affect how dolutegravir/lamivudine works. Tell your doctor if you are using any of the following:
- Dalfampridine, metformin, rifampin, sorbitol, St John's wort
- Medicine to treat seizures (including carbamazepine, oxcarbazepine, phenobarbital, phenytoin)
Take this medicine at least 2 hours before or 6 hours after you take sucralfate, or an antacid, laxative, or other medicine that contains aluminum, calcium, magnesium, or iron.
Supplements that contain calcium or iron (including multivitamins) may be taken with this medicine if you take them with food.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Do not use this medicine during the first part of your pregnancy. Use an effective form of birth control to keep from getting pregnant. Tell your doctor right away if you think you have become pregnant.
Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.
Tell your doctor if you have kidney disease or liver disease (including hepatitis B or C).
This medicine may cause the following problems:
- Liver problems
- Lactic acidosis (too much acid in the blood)
Your immune system may get stronger when you start using HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.
Always practice safe sex, even if your partner also has HIV. If you stop taking this medicine or do not take it as prescribed, you may spread HIV to others. Do not reuse or share needles, or other items, that may have blood or body fluids on them.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blistering, peeling, red skin rash
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Fast or trouble breathing, lightheadedness, fainting, severe weakness, tiredness, or confusion
Fever, chills, cough, sore throat, joint or muscle aches, severe tiredness, pain or swelling around your eyes

Last Updated: 4/23/2024