Radium ra 223 dichloride (By injection)

Radium Ra 223 Dichloride (RAY-dee-um Ra 223 dye-KLOR-ide)

Treats prostate cancer that has spread to the bones.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to radium Ra 223 dichloride.

How to Use This Medicine:


  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.
  • Drink plenty of fluids. You may become dehydrated while you are receiving this medicine.
  • Your family members must not be exposed to radiation from this medicine. The fluids from your body can transfer radiation to another person who touches them. Practice good hygiene while you receive this medicine and for at least 1 week after your last dose. Flush the toilet several times after each use. Wash clothes that are soiled with stool or urine promptly and separately from other clothes.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines may affect how radium 223 works. Tell your doctor if you are using abiraterone plus prednisone or prednisolone.

Warnings While Using This Medicine:

  • This medicine is not generally used in women, but you should know that it can harm an unborn baby if either partner is receiving it during pregnancy or conception. Men should use an effective form of birth control (including condom) during treatment and for 6 months after the last dose. Women should also use an effective form of birth control during their treatment or their partner's and for 6 months after the last dose.
  • Tell your doctor if you have kidney problems or bone marrow problems.
  • This medicine may increase your risk for fractures when used with other medicines.
  • You will be exposed to radiation with this medicine. Talk to your doctor if you have concerns about this.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bloody or black, tarry stools
  • Change in how much or how often you urinate, painful or difficult urination, bloody urine
  • Fever, chills, cough, sore throat, body aches
  • Pain or swelling in the arms or legs, bone pain
  • Tiny red dots on the skin, especially on the lower legs
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, nausea, vomiting
  • Redness, pain, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/6/2020

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