Ibuprofen (By injection)

Ibuprofen (eye-bue-PROE-fen)

Treats fever and pain. This medicine is an NSAID.

Brand Name(s):

Caldolor, Neoprofen

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
• A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Do not use aspirin or any other NSAID medicine (including diflunisal, salsalate) unless your doctor says it is okay.
• Some foods and medicines can affect how ibuprofen works. Tell your doctor if you are using any of the following:
  • Aspirin, cyclosporine, digoxin, lithium, methotrexate, pemetrexed
  • Blood thinner (including warfarin)
  • Blood pressure medicine (including ACE inhibitors, ARBs, beta blockers)
  • Diuretic (water pill)
  • Medicine to treat depression (including SNRIs, SSRIs)
  • Steroid medicine (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone)

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of pregnancy, unless your doctor tells you to.
• Tell your doctor if you have kidney disease, liver disease, asthma, bleeding problems, heart disease, recent heart attack, heart failure, high blood pressure, or a history of ulcers or other digestive problems. Tell your doctor if you drink alcohol or smoke.
• This medicine may cause the following problems:
  • Increased risk of heart attack, stroke, or heart failure
  • Stomach or bowel problems, including bleeding, ulcers, or perforation
  • Liver problems
  • High blood pressure
  • Kidney problems
  • Higher levels of potassium in the blood
  • Serious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS)
  • Changes in vision
  • Aseptic meningitis
  .
• This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blistering, peeling, or red skin rash
• Blurred vision, changes in color vision
• Change in how much or how often you urinate, difficult or painful urination
• Chest pain that may spread, trouble breathing, unusual sweating, fainting
• Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
• Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
• Fever, stiff neck, nausea or vomiting
• Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
• Rapid weight gain, swelling in your hands, ankles, or feet
• Severe stomach pain, vomiting blood, bloody or black, tarry stools
• Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

• Pain, redness, or swelling where the needle was placed
• Passing gas

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 12/4/2023