Health Encyclopedia

More <
bookmarks-menu

Drospirenone/estradiol (By mouth)

Drospirenone (droe-SPYE-re-none), Estradiol (es-tra-DYE-ol)

Treats symptoms of menopause (including hot flashes, night sweats, and vaginal problems).

Brand Name(s):

Angeliq

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to drospirenone or estradiol, if you are pregnant, or if you have adrenal gland problem or unusual vaginal bleeding that has not been checked by your doctor. Do not use it if you have kidney disease, liver disease, breast cancer, estrogen-dependent tumors (including cancer of the uterus), blood clotting problems, bleeding problems, dementia, heart or blood vessel disease, or had a heart attack or stroke.

How to Use This Medicine:

Tablet

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Swallow the tablet whole with liquid. Do not break, crush, or chew it.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. You may have vaginal bleeding if you forget to take your medicine for several days.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some foods and medicines can affect how drospirenone/estradiol works. Tell your doctor if you are using any of the following:
    • Carbamazepine, clarithromycin, diltiazem, erythromycin, itraconazole, ketoconazole, phenobarbital, rifampin, St John's wort, voriconazole
    • Blood pressure medicine (including ACE inhibitors)
    • NSAIDs or pain medicine
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

  • Pregnancy after menopause is not likely, but if you think you could be pregnant, tell your doctor. This medicine could harm an unborn baby.
  • Tell your doctor if you are breastfeeding, or if you have endometriosis, asthma, diabetes, epilepsy, hereditary angioedema, lupus, migraine headaches, porphyria, thyroid problems, edema (swelling), heart disease, high blood pressure, seizures, high cholesterol, or a history of cancer. Tell you doctor if you have had your uterus (womb) removed (hysterectomy). Tell your doctor if you have had liver problems caused by pregnancy or estrogen, if you smoke, or if you are having surgery that will require inactivity for a long time.
  • This medicine may cause the following problems:
    • Increased risk of heart attack, stroke, or blood clots
    • Increased risk of endometrial, breast, or uterine cancer
    • Increased risk of dementia (especially in women 65 years of age or older)
    • Gallbladder problem
    • Eye or vision problems
    • High blood pressure
    • High cholesterol or fats in the blood
    • Thyroid problems
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred or other changes in vision
  • Breast lumps or tenderness
  • Chest pain that may spread, trouble breathing, coughing up blood
  • Confusion, weakness, uneven heartbeat, numbness in your hands, feet, or lips
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Sudden and severe stomach pain, nausea, vomiting, fever
  • Unusual vaginal bleeding, spotting, itching, or discharge

If you notice these less serious side effects, talk with your doctor:

  • Breast pain, swelling, or tenderness
  • Headache
  • Mild stomach pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 12/4/2023

 
 
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language.

© Copyright Merative . All rights reserved