Radiological Non-ionic contrast media (By injection)

Helps parts of your body show up better during imaging tests.

Brand Name(s):

Definity, Isovue Multipack-250, Isovue Multipack-300, Isovue Multipack-370, Isovue-200, Isovue-250, Isovue-300, Isovue-370, Isovue-M 200, Isovue-M 300, Omnipaque 140, Omnipaque 180, Omnipaque 240, Omnipaque 300, Omnipaque 350

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to any contrast dye.

How to Use This Medicine:


  • A nurse or other health provider will give you this medicine. It is given through a needle placed in an artery or a vein.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • There are many medicines that can interact with a contrast dye. Make sure your doctor knows the names of all the medicines you use, especially metformin or a beta-blocker medicine.
  • Tell your doctor if you have recently received any other contrast dyes or medicines.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel problems, heart failure, a blood disorder (including anemia or sickle cell disease), diabetes, lung disease, thyroid problems, multiple sclerosis, pheochromocytoma, or multiple myeloma. Tell your doctor if you have a history of stroke, heart attack, or seizures. Tell your doctor if you have asthma, hay fever, or an allergy to any food or iodine.
  • This medicine may cause the following problems:
    • Kidney problems
    • Blood clotting problems
    • Changes in heart rhythm
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, trouble breathing, coughing up blood
  • Decrease in how much or how often you urinate, bloody or cloudy urine, lower back or side pain
  • Fast, slow, or uneven heartbeat
  • Lightheadedness, dizziness, fainting
  • Muscle stiffness or weakness, stiff joints or trouble moving, bone pain
  • Numbness or weakness on one side of your body, pain in your lower leg (calf)
  • Pain, itching, burning, redness, swelling, or a lump under your skin where the needle is placed
  • Skin rash, swelling, hardness, tightness, burning, or itching, red or dark patches
  • Sudden or severe headache, problems with vision, speech, or walking

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Mild feeling of burning, warmth, coldness when the medicine is injected
  • Nausea, vomiting
  • Warmth or redness in your face, neck, arms, or upper chest

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/6/2020

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