Dextroamphetamine (By mouth)

Dextroamphetamine (dex-troe-am-FET-a-meen)

Treats ADHD. Also treats narcolepsy.

Brand Name(s):

Dexedrine Spansule, ProCentra, Zenzedi

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to dextroamphetamine, amphetamine, or similar medicines, or if you have glaucoma, an overactive thyroid, or a history of drug abuse.

How to Use This Medicine:

Long Acting Capsule, Liquid, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Short-acting tablet: Take your last dose of the day at least 6 hours before bedtime, unless your doctor gives you other instructions.
  • Extended-release capsule: It is best to take this medicine in the morning. You may have trouble falling asleep at night if you take it in the afternoon or evening.
  • Swallow the extended-release capsule whole. Do not crush, break, or chew it.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine if you are using or have used an MAO inhibitor within the past 14 days.
  • Some foods and medicines can affect how dextroamphetamine works. Tell your doctor if you are also using any of the following:
    • Acetazolamide, ammonium chloride, antacids, buspirone, chlorpromazine, ethosuximide, fentanyl, glutamic acid, guanethidine, haloperidol, hydrochlorothiazide, lithium, meperidine, methenamine, omeprazole, phenobarbital, phenytoin, propoxyphene, quinidine, reserpine, ritonavir, sodium acid phosphate, sodium bicarbonate, St John's wort, tramadol, or tryptophan supplement
    • Allergy medicine
    • Blood pressure medicine
    • Medicine to treat depression (including desipramine, fluoxetine, paroxetine, protriptyline)
    • Medicine to treat migraine headaches
  • Fruit juice and vitamin C can affect how your body absorbs this medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart or blood vessel disease, heart rhythm problems, high blood pressure, thyroid problems, Tourette syndrome, or a history of heart attack, stroke, or seizures. Tell your doctor if you or anyone in your family has a history of depression, mental health problems, or drug or alcohol abuse.
  • This medicine may cause the following problems:
    • Sudden death in people who have heart defects
    • Serious heart or blood vessel problems, including heart attack and stroke
    • Unusual changes in behavior or mood
    • Slow growth in children
    • Peripheral vasculopathy (a blood circulation problem)
    • Serotonin syndrome (when used with certain medicines)
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • This medicine may make you dizzy or cause blurred vision. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Blurred vision or vision changes
  • Chest pain that may spread, trouble breathing, nausea, unusual sweating, faintness
  • Extreme energy or restlessness, confusion, agitation, unusual moods or behaviors
  • Fast, pounding, or uneven heartbeat
  • Lightheadedness, dizziness, fainting
  • Numb, cold, pale, or painful fingers or toes, unexplained wounds on your fingers or toes
  • Seeing, hearing, or feeling things that are not there
  • Seizure

If you notice these less serious side effects, talk with your doctor:

  • Dry mouth, diarrhea, stomach pain
  • Loss of appetite, weight loss
  • Trouble sleeping

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/6/2020

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