Conjugated estrogens/medroxyprogesterone (By mouth)
Conjugated Estrogens (KON-joo-gay-ted ES-troe-jenz), Medroxyprogesterone Acetate (me-drox-ee-proe-JES-ter-one AS-e-tate)
Treats hot flashes, other symptoms of menopause, and vaginal dryness after menopause. Also prevents osteoporosis after menopause. This medicine is a combination of 2 hormones.
Brand Name(s):
Premphase, Prempro, Prempro Low Dose
There may be other brand names for this medicine.When This Medicine Should Not Be Used:
This medicine is not right for everyone. Do not use it if you had an allergic reaction to estrogen or progestin, or if you have liver disease, breast cancer, or estrogen-dependent tumors. Do not use it if you have bleeding problems, blood clots, dementia, heart or blood vessel disease, or had a heart attack or stroke. Do not use this medicine if you may be pregnant, or if you have unusual vaginal bleeding that has not been checked by your doctor.How to Use This Medicine:
Tablet
- Your doctor will tell you how much medicine to use. Do not use more than directed.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines and foods can affect how this medicine works. Tell your doctor if you are using carbamazepine, clarithromycin, erythromycin, itraconazole, ketoconazole, phenobarbital, rifampin, ritonavir, or St John's wort.
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- Pregnancy after menopause is not likely, but if you think you could be pregnant, tell your doctor. This medicine could harm an unborn baby.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, asthma, diabetes, edema (body swelling), endometriosis, epilepsy, migraine headaches, porphyria, lupus, thyroid problems, heart disease, high blood pressure, high cholesterol or triglycerides (fats) in the blood, inherited angioedema, or a history of cancer. Tell your doctor if you have had your uterus removed (hysterectomy) or if you are having surgery that will require inactivity for a long time.
- This medicine may cause the following problems:
- Increased risk of heart attack, stroke, or blood clots
- Increased risk of endometrial cancer, breast cancer, or uterine cancer
- Increased risk of dementia, especially in females 65 years of age and older
- Gallbladder disease
- Eye or vision problems
- High blood pressure
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results. You may need to stop using this medicine for a few weeks before and after you have surgery or if you need to stay in bed for a long time, because of the risk of blood clots.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You should have regular exams and mammograms as directed by your doctor.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Breast lumps or tenderness
- Chest pain that may spread, trouble breathing, nausea, coughing up blood
- Confusion, weakness, uneven heartbeat, numbness in your hands, feet, or lips
- Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
- Sudden or severe stomach pain, nausea, vomiting
- Unusual or unexpected vaginal bleeding or heavy bleeding
- Vision changes, vision loss, double vision, migraine headache
If you notice these less serious side effects, talk with your doctor:
- Light vaginal bleeding or spotting
- Mild stomach pain or cramps, stomach upset
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 7/10/2025
