Unoprostone (Into the eye)

Unoprostone (oo-noe-PROE-stone)

Treats open-angle glaucoma and other conditions. Lowers pressure inside the eye.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to unoprostone or benzalkonium chloride.

How to Use This Medicine:


  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • If you wear contact lenses, remove them before putting the medicine in your eyes. Wait at least 15 minutes after you apply the drops before putting the lenses back in.
  • Wash your hands before and after using the medicine.
  • Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.
  • Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball.
  • Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute.
  • Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away.
  • If you are using any other eye drops, wait at least 5 minutes after using unoprostone before you put the other drops in your eyes.
  • Never share your medicine with anyone.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose.
  • Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Keep the bottle upright when you are not using it.
  • Store the medicine at room temperature, away from heat and direct light.
  • Keep all medicine out of the reach of children.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, kidney disease, or any inflammation of the eye.
  • If you hurt your eye, develop an eye infection, or need to have eye surgery, talk to your doctor right away. You may need to change your medicine or stop using it.
  • This medicine may permanently change the color of your eyes, causing an increase in the amount of brown pigment in the iris (the colored part of the eye). This change may not be noticeable for several months or years.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in face or hands, swelling or tingling in the mouth or throat, tightness in chest, trouble breathing
  • Redness, swelling, or pain in the eye or eyelid
  • Watering or other discharge from the eye

If you notice these less serious side effects, talk with your doctor:

  • Burning or stinging of the eye, sometimes occurring when you put the drops in the eye
  • Change in length of eyelashes
  • Dry or itchy eyes
  • Feeling that something is in your eye
  • Flu-like symptoms

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/6/2020

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