Quinupristin/dalfopristin (By injection)

Dalfopristin (dal-foe-PRIS-tin), Quinupristin (kwin-ue-PRIS-tin)

Treats infections caused by bacteria. Belongs to a class of drugs called antibiotics.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have ever had an allergic reaction to quinupristin, dalfopristin, or similar medicines such as pristinamycin or virginiamycin.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and tell you how often it will be given.
  • Your medicine will be given directly into a vein, usually in your arm or chest. This is called intravenous (in-tra-VEEN-ous), or IV.
  • A nurse or other caregiver trained to give IV infusions will give your medicine.

If a dose is missed:

  • It is very important to use this medicine on a regular schedule. Make sure your doctor knows if you miss a dose.

How to Store and Dispose of This Medicine:

  • If you store this medicine at home, it is best to keep it in the refrigerator. Do not freeze.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Before using this medicine, tell your doctor if you are using cyclosporine, nifedipine (Procardia®), or midazolam (Versed®).

Warnings While Using This Medicine:

  • If you are pregnant or breastfeeding, talk to your doctor before using this medicine.
  • Make sure your doctor knows if you have liver disease before using this medicine.
  • If your infection does not improve, or if it gets worse while using this medicine, talk to your doctor.
  • If you have severe diarrhea while using this medicine, check with your doctor before taking medicine to stop the diarrhea.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Severe diarrhea (watery or bloody)
  • Swelling, pain, or redness near where your IV is located
  • Yellowing of your skin or eyes

If you notice these less serious side effects, talk with your doctor:

  • Joint or muscle pain
  • Mild diarrhea
  • Mild rash or itching
  • Nausea and/or vomiting

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/6/2020

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