Simvastatin (By mouth)

Simvastatin (sim-va-STAT-in)

Lowers high cholesterol and triglyceride levels. May reduce the risk of heart attack, stroke, and related health conditions. This medicine is a statin.

Brand Name(s):

FloLipid, Zocor

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to simvastatin, if you are pregnant or breastfeeding, or if you have active liver disease.

How to Use This Medicine:

Suspension, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Take the medicine in the evening, unless your doctor tells you otherwise.
  • Oral liquid:
    • Take this medicine on the evening, on an empty stomach.
    • Shake the oral suspension well for at least 20 seconds before using it.
    • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with boceprevir, clarithromycin, cobicistat, cyclosporine, danazol, erythromycin, gemfibrozil, itraconazole, ketoconazole, nefazodone, posaconazole, telaprevir, telithromycin, voriconazole, or medicines to treat HIV/AIDS.
  • Do not use this medicine together with niacin if you are Chinese or have Chinese ancestry.
  • Some foods and medicines can affect how simvastatin works. Tell your doctor if you are using any of the following:
    • Amiodarone, colchicine, daptomycin, digoxin, dronedarone, lomitapide, niacin (vitamin B3), ranolazine
    • Blood pressure medicine (including amlodipine, diltiazem, verapamil)
    • Blood thinner (including warfarin)
    • Fibrate medicine
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you have kidney disease, diabetes, thyroid disease, blood vessel disease, low blood pressure, seizures, or a history of stroke or heart disease. Tell your doctor if you drink alcohol regularly or have a history of liver disease. Tell your doctor if you are Chinese or have Chinese ancestry.
  • This medicine may cause liver problems, or myopathy or rhabdomyolysis (severe muscle damage).
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fast or uneven heartbeat
  • Trouble breathing
  • Unexplained muscle pain, tenderness, or weakness
  • Unusual tiredness

If you notice these less serious side effects, talk with your doctor:

  • Constipation
  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/6/2020

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