Lansoprazole (By mouth)

Lansoprazole (lan-SOE-pra-zole)

Treats stomach ulcers, a damaged esophagus, gastroesophageal reflux disease (GERD), and conditions that cause your stomach to make too much acid, including Zollinger-Ellison syndrome. This medicine is a proton pump inhibitor (PPI).

Brand Name(s):

First-Lansoprazole, Good Sense Lansoprazole, Prevacid, Prevacid SoluTab, Prevpac, Topcare Lansoprazole

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to lansoprazole.

How to Use This Medicine:

Delayed Release Capsule, Liquid, Packet, Tablet Disintegrating, Delayed Release

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Follow the instructions on the medicine label if you are using this medicine without a prescription.
  • Take this medicine before you eat and for the full treatment time, even if you begin to feel better after a few days.
  • Delayed-release capsule: Swallow the capsule whole. Do not break, crush, or chew it.
    • If you cannot swallow the capsule, you may open it and mix the contents in 1 tablespoon of applesauce, Ensure® pudding, cottage cheese, yogurt, or strained pears. You may also use 1/4 cup (60 milliliters [mL]) of apple, orange, or tomato juice. Swallow this mixture right away without chewing. If you use juice, refill the cup 2 more times and drink it right away to make sure you get the full dose.
    • To prepare for a feeding tube:
      • Open the capsule and mix the contents with 40 mL of apple juice. Do not use any other liquids.
      • Inject or pour the mixture into the tube.
      • Flush the tube with more apple juice to make sure the full dose is given.
  • Delayed-release disintegrating tablet: Dry your hands before you handle the tablet. Do not crush, chew, break, or cut the tablet. Place the tablet on your tongue and allow it to dissolve. Once the tablet dissolves, swallow it right away.
    • To prepare for an oral syringe:
      • Place the tablet in the oral syringe. Add 4 mL of water for the 15 milligram (mg) tablet or 10 mL of water for the 30 mg tablet.
      • Shake the syringe gently until the tablet dissolves.
      • Use the mixture within 15 minutes.
      • To make sure the full dose is given, refill the syringe with water. Use 2 mL of water for the 15 mg tablet or 5 mL for the 30 mg tablet. Shake the syringe gently and give the mixture.
    • To prepare for a feeding tube:
      • Place the tablet in the syringe. Add 4 mL of water for the 15 mg tablet or 10 mL for the 30 mg tablet.
      • Shake the syringe gently until the tablet dissolves.
      • Inject or pour the mixture into the tube within 15 minutes.
      • Refill the syringe with 5 mL of water and shake it gently. Flush the tube with the water to make sure the full dose is given.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine if you are also using products containing rilpivirine.
  • Lansoprazole affects digestion and may keep other medicines from working correctly. Tell your doctor if you are using any of the following:
    • Ampicillin, atazanavir, dasatinib, digoxin, erlotinib, itraconazole, ketoconazole, methotrexate, mycophenolate mofetil, nelfinavir, nilotinib, rifampin, saquinavir, St John's wort, tacrolimus, theophylline, voriconazole
    • Blood thinner (including warfarin)
    • Diuretic (water pill)
    • Iron supplements
  • If you are also using sucralfate, take it 30 minutes after you take lansoprazole.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lupus, osteoporosis, vitamin B12 deficiency, or phenylketonuria (PKU).
  • This medicine may cause the following problems:
    • Kidney problems
    • Increased risk of broken bones in the hip, wrist, or spine (more likely if used several times per day or longer than 1 year)
    • Lupus
    • Fundic gland polyps (abnormal growth in the upper part of your stomach)
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Fever, swelling in your body, unusual weight gain, change in how much or how often you urinate
  • Joint pain, rash on your cheeks or arms that gets worse in the sun
  • Seizures, dizziness, fast or uneven heartbeat, muscle cramps or twitching
  • Severe diarrhea that does not go away, stomach cramps

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/6/2020

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