Quinestrol (By mouth)

Quinestrol (kwin-ES-trol)

Treats symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer. Belongs to a class of drugs called estrogens.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have ever had an allergic reaction to estrogens, if you are pregnant or breastfeeding, or you have abnormal vaginal bleeding. You should not use if you have had a blood clot.

How to Use This Medicine:


  • Your doctor will tell you how much medicine to take and how often.

If a dose is missed:

  • Take the missed dose as soon as possible.
  • Skip the missed dose if it is almost time for your next regular dose.
  • You should not use two doses at the same time.

How to Store and Dispose of This Medicine:

  • Store at room temperature; protect from heat, moisture, and direct light.
  • Keep all medicine out of the reach of children.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you are taking insulin or blood thinners (such as Coumadin®).

Warnings While Using This Medicine:

  • Check with your doctor before taking this medicine if you have diabetes, asthma, epilepsy, migraine headaches, depressed mood, or heart, liver, or kidney disease.
  • Large doses of estrogens taken over long periods of time may increase the risk of some kinds of cancer. Talk to your doctor about this risk.
  • Unless you have had a hysterectomy (uterus removed), ask your doctor whether you should also take progesterone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Severe stomach pain or swelling
  • Heavy vaginal bleeding
  • Pain or numbness in chest, groin, or leg (calf)
  • Weak or numb arm or leg
  • Shortness of breath
  • Severe headache, dizziness, or changes in vision
  • Severe vomiting
  • Breast lumps
  • Yellow skin or eyes

If you notice these less serious side effects, talk with your doctor:

  • Mild nausea or vomiting
  • Bloated feeling
  • Mild dizziness
  • Headache
  • Change in sexual desire
  • Swollen or tender breasts
  • Fluid retention and weight gain
  • Contact lens discomfort
  • Depressed mood

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/6/2020

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