Fenoprofen (By mouth)

Fenoprofen (fen-oh-PROE-fen)

Treats pain and arthritis. This medicine is an NSAID.

Brand Name(s):

Fenortho, Nalfon

When This Medicine Should Not Be Used:

How to Use This Medicine:

Capsule, Tablet

• Your doctor will tell you how much medicine to use. Do not use more than directed.
• It is best to take this medicine with food or milk, so it does not upset your stomach.
• Swallow the capsule or tablet whole. Do not break, crush, divide, or chew it.
• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
• Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Do not use any other NSAID medicine (including aspirin, diflunisal, salsalate) unless your doctor tells you otherwise.
• Some foods and medicines can affect how this medicine works. Tell your doctor if you are using any of the following:
  • Cyclosporine, diflunisal, digoxin, lithium, methotrexate, pemetrexed, phenobarbital
  • Blood pressure medicine (including ACE inhibitors, ARBs, beta blockers)
  • Blood thinner (including warfarin)
  • Diuretic (water pill)
  • Medicine to treat depression (including SNRIs, SSRIs)
  • Steroid medicine
  • Sulfa drug

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy.
• Tell your doctor if you have kidney disease, liver disease, asthma, bleeding problems, congestive heart failure, high blood pressure, or other heart problems, hearing problems, or a history of stomach problems (including stomach bleeding or ulcers).
• This medicine may cause the following problems:
  • Increased risk of blood clots, heart attack, stroke, or heart failure
  • Stomach or bowel problems, including bleeding, ulcers, or perforation
  • Liver problems
  • High blood pressure
  • Kidney problems
  • Serious skin reactions, including Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, fixed drug eruption (FDE), and generalized bullous fixed drug eruption (GBFDE)
  • Drug reaction with eosinophilia and systemic symptoms (DRESS)
  • Eye or vision problems
• This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
• Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blistering, peeling, red skin rash
• Change in how much or how often you urinate, painful urination
• Chest pain, trouble breathing, coughing up blood
• Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
• Fast, slow, or pounding heartbeat
• Numbness or weakness on one side of your body
• Severe stomach pain, vomiting blood, bloody, black or tarry stools
• Sudden or severe headache, or problems with vision, speech, or walking
• Unusual bleeding, bruising, or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 2/4/2025