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Adagrasib (By mouth)

Adagrasib (a-DA-gra-sib)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction adagrasib.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Take the medicine at the same time each day.
Swallow the tablet whole. Do not chew, crush, or split it.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: If a dose is missed by more than 4 hours or if you vomit after you take a dose, do not take an extra dose. Take the next dose at the regular scheduled time. Do not take extra medicine to make up for the missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Some medicines can affect how adagrasib works. Tell your doctor if you are using dextromethorphan, digoxin, midazolam, rifampin, warfarin, or medicine that may cause heart rhythm problems.

Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, or heart disease (including heart failure and congenital QT syndrome).
Do not breastfeed while you are using this medicine and for at least 1 week after your last dose.
This medicine may cause the following problems:
- Serious stomach and bowel problems (including bleeding, blockage, swelling, narrowing)
- Heart rhythm problems, including QT prolongation, torsade de pointes
- Liver problems
- Lung or breathing problems, including interstitial lung disease (ILD), pneumonitis
Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
Cancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.
This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Change in how much or how often you urinate
Constipation, diarrhea, nausea, vomiting, stomach pain, blood in the stools
Dark urine or pale stools, loss of appetite, yellow skin or eyes
Fainting, dizziness, lightheadedness
Fast, pounding, or uneven heartbeat
Muscle or bone pain
Rapid weight gain, swelling in your hands, ankles, or feet

Last Updated: 12/4/2023