Trilaciclib (By injection)

Trilaciclib (trye-la-SYE-klib)

Helps reduce bone marrow problem caused by cancer treatment for lung cancer.

Brand Name(s):

Cosela

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. This medicine must be given slowly, so the needle will have to remain in place for at least 30 minutes. It is given within 4 hours before you receive your cancer treatment.
• A nurse or other health provider will give you this medicine.
• Missed dose: Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how trilaciclib works. Tell your doctor if you are using cisplatin, dalfampridine, or dofetilide.

Warnings While Using This Medicine:

• It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Use an effective form of birth control during treatment and for at least 3 weeks after the last dose.
• Do not breastfeed during treatment and for at least 3 weeks after the last dose.
• Tell your doctor if you have liver disease or lung problems.
• This medicine may cause the following problems:
  • Serious injection-site reactions (including phlebitis, thrombophlebitis)
  • Lung or breathing problems (including interstitial lung disease, pneumonitis)
• This medicine could cause infertility in some women. Talk with your doctor before using this medicine if you plan to have children.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Chest pain, trouble breathing, coughing up blood
• Dry mouth, increased thirst, muscle cramps, nausea or vomiting, uneven heartbeat
• Fever, chills, cough, sore throat, body aches
• Headache
• Numbness, tingling, or burning pain in your hands, arms, legs, or feet
• Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
• Seizures
• Unusual bleeding, bruising, tiredness, or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/23/2024