Mitomycin (By injection)
Treats low-grade upper tract urothelial cancer (cancer of the lining of the upper urinary tract).
Brand Name(s):There may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. You should not receive it if you had an allergic reaction to mitomycin, if you have a hole or tear in your bladder or upper urinary tract, or if you are pregnant.
How to Use This Medicine:
- Your doctor will prescribe your dose and schedule. This medicine is given to your kidney through a tube called a catheter.
- You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
- Your doctor will tell you to take sodium bicarbonate before each treatment with this medicine. Follow your doctor's instructions about how and when to take this.
- Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some foods and medicines can affect how mitomycin works. Tell your doctor if you are using a diuretic (water pill).
Warnings While Using This Medicine:
- This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective form of birth control during treatment with this medicine and for at least 6 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for at least 3 months after the last dose.
- Do not breastfeed during treatment with this medicine and for at least 1 week after the last dose.
- Tell your doctor if you have kidney disease, liver disease or blood or bone marrow problems.
- This medicine may cause swelling and narrowing of the ureter (tube that carries urine from the kidney to the bladder).
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate, red or dark brown urine
- Fever, chills, lower back or side pain
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Nausea, vomiting, stomach pain
- Skin itching
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 3/29/2022