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Tazemetostat (By mouth)

Tazemetostat (taz-e-MET-oh-stat)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to tazemetostat, or if you are pregnant or breastfeeding.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Swallow the tablet whole. Do not crush, break, or chew it.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Missed dose: If you miss a dose or vomit after taking your dose, skip that dose and take the next dose at your regular schedule.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Some medicines can affect how tazemetostat works. Tell your doctor if you are using fluconazole, midazolam, repaglinide, or St John's wort.
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Birth control pills may not work as well while you are using this medicine. Use an effective form of birth control (including condoms) to keep from getting pregnant during treatment and for at least 6 months after your last dose. Males with female partners must use effective birth control during and for at least 3 months after the last dose of this medicine.
Do not breastfeed during treatment and for at least 1 week after your last dose.
Tell your doctor if you have kidney disease or liver disease.
This medicine may increase your risk of getting other cancers (including leukemia, lymphoma, myelodysplastic syndrome).
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Bloody or cloudy urine, change in how much or how often you urinate, difficult, burning, or painful urination
Chest pain, trouble breathing
Fever, chills, cough, stuffy or runny nose, sore throat, body aches
Muscle or bone pain, paleness, tiredness
Unusual bleeding, bruising, or weakness

Last Updated: 12/4/2023