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Cenobamate (By mouth)

Cenobamate (sen-oh-BAM-ate)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to cenobamate.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Swallow the tablet whole. Do not crush, break, or chew it.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Some medicines can affect how cenobamate works. Tell your doctor if you are using bupropion, carbamazepine, clobazam, lamotrigine, midazolam, omeprazole, phenobarbital, phenytoin, or birth control pills.
Do not drink alcohol while you are using this medicine.
Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart rhythm problems (including familial short QT syndrome), depression, or mental illness.
This medicine may cause the following problems:
- Heart rhythm problems (including QT shortening)
- Serious skin reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS).
This medicine may make you dizzy, drowsy, or clumsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Bloody or cloudy urine, troubled breathing, swelling of the face, feet, or lower legs
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Fast, pounding, or uneven heartbeat, fainting
Fever, skin rash, or swollen, painful, or tender lymph glands in neck, armpit, or groin
Unusual changes in mood or behavior, unusual thoughts, trouble sleeping

Last Updated: 12/4/2023